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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf3tm1Ttg
targeted mutation 1, Tadatsugu Taniguchi
MGI:3577601
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irf3tm1Ttg/Irf3tm1Ttg B6.129-Irf3tm1Ttg MGI:6384854
hm2
 		Irf3tm1Ttg/Irf3tm1Ttg involves: 129S/SvEv * C57BL/6 MGI:4353429
hm3
 		Irf3tm1Ttg/Irf3tm1Ttg involves: 129S/SvEv * C57BL/6J MGI:3577602
cx4
 		Irf3tm1Ttg/Irf3tm1Ttg
Irf7tm1Ttg/Irf7tm1Ttg 		involves: 129P2/OlaHsd * 129S/SvEv MGI:4442206
cx5
 		Irf3tm1Ttg/Irf3tm1Ttg
Irf9tm1Ttg/Irf9tm1Ttg 		involves: 129S/SvEv * C57BL/6J MGI:3577612
cx6
 		Irf3tm1Ttg/Irf3tm1Ttg
Sting1em1Jmin/Sting1em1Jmin 		involves: 129S/SvEv * C57BL/6N MGI:6302792


Genotype
MGI:6384854
hm1
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Genetic
Background		 B6.129-Irf3tm1Ttg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina outer nuclear layer morphology ( J:281010 )
• photoreceptor synaptic terminals withdrawn from OPL into ONL at age 3-4 months
• Pkca-positive rod bipolar cell dendrites and calbindin positive horizontal cell neurites extend further into ONL than normal at age 3-4 months
• normal synapse locations at age P7 and P21
thin retina outer nuclear layer ( J:281010 )
• at age 3-4 months and 22-24 months
retina outer nuclear layer degeneration ( J:281010 )
• at age 3-4 months and 22-24 months
abnormal retina outer plexiform layer morphology ( J:281010 )
• normal synapse locations at age P7 and P21
• photoreceptor synaptic terminals withdrawn from OPL into ONL at age 3-4 months
• ectopic synapses on rod bipolar cell sprouts at age 3-4 months
• decreased synapse density at age 3-4 months and 22-24 months
thin retina outer plexiform layer ( J:281010 )
• at age 3-4 months and 22-24 months
decreased total retina thickness ( J:281010 )
• at age 3-4 months and 22-24 months
• normal at age P7 and P21
retina degeneration ( J:281010 )
• at age 3-4 months and 22-24 months
decreased a-wave amplitude ( J:281010 )
• using scotopic flash ERG at age 3-4 months and 22-24 months
decreased b-wave amplitude ( J:281010 )
• using scotopic flash ERG at age 3-4 months and 22-24 months




Genotype
MGI:4353429
hm2
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to ultraviolet irradiation ( J:150948 )
• embryonic fibroblasts are resistant to apoptosis to caused by UV irradiation




Genotype
MGI:3577602
hm3
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal circulating interferon level ( J:98127 )
• encephalomyocarditis virus infected mutants had significantly lower interferon levels in serum compared to wildtype
increased susceptibility to Picornaviridae infection ( J:98127 )
• more vulnerable to encephalomyocarditis virus infection with all mutants dying within 6 days compared to wildtype, in which 40% recovered from infection

homeostasis/metabolism
abnormal circulating interferon level ( J:98127 )
• encephalomyocarditis virus infected mutants had significantly lower interferon levels in serum compared to wildtype




Genotype
MGI:4442206
cx4
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Irf7tm1Ttg/Irf7tm1Ttg
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
Irf7tm1Ttg mutation (2 available); any Irf7 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-beta secretion ( J:158969 )
• F. tularensis live vaccine strain-, Sendai virus-, or synthetic B-form dsDNA (poly-dA:dT)-treated thioglycollate-elicited macrophages secrete less IFN-beta than similarly treated wild-type cells
• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells
decreased interleukin-1 beta secretion ( J:158969 )
• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B than similarly treated wild-type cells
• however, synthetic B-form dsDNA (poly-dA:dT)-treated mice produce normal amounts of IL1-beta
increased susceptibility to bacterial infection ( J:158969 )
• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B and IFN-beta than similarly treated wild-type cells
increased susceptibility to Herpesvirales infection ( J:158969 )
• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells
increased susceptibility to Paramyxoviridae infection ( J:158969 )
• Sendai virus-treated splenocytes secrete less IFN-beta than similarly treated wild-type cells




Genotype
MGI:3577612
cx5
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Irf9tm1Ttg/Irf9tm1Ttg
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
Irf9tm1Ttg mutation (2 available); any Irf9 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:98127 )
• Newcastle disease virus infected MEFs had undetectable interferon-alpha/beta activity, indicating that mutant MEFs are incapable of responding to infection




Genotype
MGI:6302792
cx6
Allelic
Composition		 Irf3tm1Ttg/Irf3tm1Ttg
Sting1em1Jmin/Sting1em1Jmin
Genetic
Background		 involves: 129S/SvEv * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf3tm1Ttg mutation (3 available); any Irf3 mutation (37 available)
Sting1em1Jmin mutation (1 available); any Sting1 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased single-positive T cell number ( J:251372 )
• the percent and absolute number of CD8+ T cells in spleen is reduced to a similar level as in single Sting1em1Jmin homozygotes
increased myeloid cell number ( J:251372 )
• spleen shows a similar increase in the number of Ly6G+ and Ly6C+ myeloid cell populations as in single Sting1em1Jmin homozygotes

immune system
decreased single-positive T cell number ( J:251372 )
• the percent and absolute number of CD8+ T cells in spleen is reduced to a similar level as in single Sting1em1Jmin homozygotes
lung inflammation ( J:251372 )
• mice exhibit a similar level of perivascular immune cell infiltration as single Sting1em1Jmin homozygotes

respiratory system
lung inflammation ( J:251372 )
• mice exhibit a similar level of perivascular immune cell infiltration as single Sting1em1Jmin homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory