All Phenotypes Pip5k1b<tm1Tssk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pip5k1b^tm1Tssk
targeted mutation 1, Takehiko Sasaki
MGI:3577649

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pip5k1b^tm1Tssk/Pip5k1b^tm1Tssk	involves: 129P2/OlaHsd	MGI:3798058
hm2	Pip5k1b^tm1Tssk/Pip5k1b^tm1Tssk	involves: 129P2/OlaHsd * C57BL/6	MGI:3579078
cx3	Pip5k1a^tm1.1Tba/Pip5k1a^tm1.1Tba Pip5k1b^tm1Tssk/Pip5k1b^tm1Tssk	involves: 129P2/OlaHsd	MGI:5430945

Allelic Composition	Pip5k1b^tm1Tssk/Pip5k1b^tm1Tssk
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip5k1b^tm1Tssk mutation (1 available); any Pip5k1b mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced male fertility ( J:185835 )

• however, in vitro fertilization frequency is normal

impaired fertilization ( J:185835 )

decreased fertilization frequency ( J:185835 )

hematopoietic system

hematopoietic system phenotype ( J:131289 )

N	• megakaryocytes derived from femurs do not have a defect in their ability to anchor their cell membrane to the underlying cytoskeleton

Allelic Composition	Pip5k1b^tm1Tssk/Pip5k1b^tm1Tssk
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip5k1b^tm1Tssk mutation (1 available); any Pip5k1b mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mast cell physiology ( J:97991 )

• Fc-epsilon-receptor-I-evoked degranulation was increased in bone marrow derived mast cells

increased susceptibility to type I hypersensitivity reaction ( J:97991 )

• exhibited a greater degree of IgE-dependent systemic anaphylaxis and passive cutaneous anaphylaxis

hematopoietic system

abnormal mast cell physiology ( J:97991 )

• Fc-epsilon-receptor-I-evoked degranulation was increased in bone marrow derived mast cells

Allelic Composition	Pip5k1a^tm1.1Tba/Pip5k1a^tm1.1Tba Pip5k1b^tm1Tssk/Pip5k1b^tm1Tssk
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip5k1a^tm1.1Tba mutation (1 available); any Pip5k1a mutation (67 available)
Pip5k1b^tm1Tssk mutation (1 available); any Pip5k1b mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:185835 )

abnormal sperm midpiece morphology ( J:185835 )

coiled sperm flagellum ( J:185835 )

• some sperm exhibit tails around the head

detached sperm flagellum ( J:185835 )

• some sperm exhibit snapped flagellum necks

oligozoospermia ( J:185835 )

decreased testis weight ( J:185835 )

abnormal spermiation ( J:185835 )

abnormal reproductive system physiology ( J:185835 )

asthenozoospermia ( J:185835 )

male infertility ( J:185835 )

impaired fertilization ( J:185835 )

• absent

decreased fertilization frequency ( J:185835 )

• absent

endocrine/exocrine glands

decreased testis weight ( J:185835 )

cellular

abnormal sperm midpiece morphology ( J:185835 )

coiled sperm flagellum ( J:185835 )

• some sperm exhibit tails around the head

detached sperm flagellum ( J:185835 )

• some sperm exhibit snapped flagellum necks

oligozoospermia ( J:185835 )

asthenozoospermia ( J:185835 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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