Phenotypes associated with this allele

• Allele Symbol: Nfkbia^tm1.1Kbp
• Allele Name: targeted mutation 1, Klaus Pfeffer
• Allele ID: MGI:3577710
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkbia^tm1.1Kbp/Nfkbia^tm1.1Kbp	involves: 129P2/OlaHsd * C57BL/6	MGI:3579002

Genotype
MGI:3579002

hm1

• Allelic Composition: Nfkbia^tm1.1Kbp/Nfkbia^tm1.1Kbp
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:97945 )

• mice are born at Mendelian frequencies, but die between days 6 and 7

growth/size/body

postnatal growth retardation ( J:97945 )

• suffered from severe growth retardation starting at 3 days after birth

• at 5 days after birth their weight was about one-half of wild-type

hematopoietic system

abnormal erythropoiesis ( J:97945 )

• an increase in Ter-119^hi cells of the erythropoietic lineage in the liver of 3- and 5-day-old mice and in the bone marrow

increased bone marrow cell number ( J:97945 )

• approximately a 2-fold increase in the number of bone marrow derived granulocyte/erythroid/monocyte/macrophage colony-forming units

abnormal granulocyte morphology ( J:97945 )

• elevated white blood cell counts with dysplasia of the neutrophil in peripheral blood

increased granulocyte number ( J:97945 )

• marked increase in Gr-1^hi/Mac-1^hi granulocyte in the liver of 3- and 5-day-old mice and in the bone marrow

immune system

abnormal granulocyte morphology ( J:97945 )

• elevated white blood cell counts with dysplasia of the neutrophil in peripheral blood

increased granulocyte number ( J:97945 )

• marked increase in Gr-1^hi/Mac-1^hi granulocyte in the liver of 3- and 5-day-old mice and in the bone marrow