All Phenotypes Plcg2<Ali5> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plcg2^Ali5
Abnormal limb 5
MGI:3577720

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcg2^Ali5/Plcg2^Ali5	involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5	MGI:3578557
ht2	Plcg2^Ali5/Plcg2⁺	C3HeB/FeJ-Plcg2^Ali5	MGI:3578555
ht3	Plcg2^Ali5/Plcg2⁺	involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5	MGI:3578556
cx4	Igh^tm1.1Twin/Igh^tm1.1Twin Plcg2^Ali5/Plcg2⁺	involves: 129 * 129S4/SvJae * C3HeB/FeJ * C57BL/6	MGI:5140412
cx5	Plcg2^Ali5/Plcg2⁺ Rag1^tm1Mom/Rag1^tm1Mom	involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5	MGI:3578558

Allelic Composition	Plcg2^Ali5/Plcg2^Ali5
Genetic Background	involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2^Ali5 mutation (0 available); any Plcg2 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased transitional stage B cell number ( J:97930 )

• reduction of transitional T2 B cells

decreased mature B cell number ( J:97930 )

• reduction of mature B cells

abnormal B cell physiology ( J:97930 )

• 66% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype

chronic inflammation ( J:97930 )

• approximately 90% of homozygous mice had severe inflammation of the paws

• they also developed severe keratitis

glomerulonephritis ( J:97930 )

• proliferative intra- and extracapillary glomerulonephritis in eight out of eight

renal/urinary system

glomerulonephritis ( J:97930 )

• proliferative intra- and extracapillary glomerulonephritis in eight out of eight

hematopoietic system

decreased transitional stage B cell number ( J:97930 )

• reduction of transitional T2 B cells

decreased mature B cell number ( J:97930 )

• reduction of mature B cells

abnormal B cell physiology ( J:97930 )

• 66% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype

Allelic Composition	Plcg2^Ali5/Plcg2⁺
Genetic Background	C3HeB/FeJ-Plcg2^Ali5

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2^Ali5 mutation (0 available); any Plcg2 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B-2 B cell number ( J:97930 )

• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number

abnormal B cell physiology ( J:97930 )

• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells

• anti-DNA antibodies were not detected

chronic inflammation ( J:97930 )

• mice have normal paws at birth but gradually develop swollen and deformed

• male mice were affected earlier at 2 months than female at 8-10 months

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears

skeleton

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

hematopoietic system

decreased B-2 B cell number ( J:97930 )

• 50% of heterozygous mutant had an abnormally high ratio of T cells versus mature B cells due to a reduction in the B2 cell number

abnormal B cell physiology ( J:97930 )

• the response in vitro to the mitogens LPS, anti CD40, and IL4 plus anti-IgM was higher for splenic B cells

• anti-DNA antibodies were not detected

integument

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears

Allelic Composition	Plcg2^Ali5/Plcg2⁺
Genetic Background	involves: C57BL/6J * C3HeB/FeJ-Plcg2^Ali5

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2^Ali5 mutation (0 available); any Plcg2 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:97930 )

N	• no chronic inflammation of the paw was observed

abnormal B cell physiology ( J:97930 )

• 28% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype

glomerulonephritis ( J:97930 )

• in three out of ten

renal/urinary system

glomerulonephritis ( J:97930 )

• in three out of ten

hematopoietic system

abnormal B cell physiology ( J:97930 )

• 28% of heterozygous mice exhibit high anti-DNA antibody titers of the IgG isotype

Allelic Composition	Igh^tm1.1Twin/Igh^tm1.1Twin Plcg2^Ali5/Plcg2⁺
Genetic Background	involves: 129 * 129S4/SvJae * C3HeB/FeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Twin mutation (0 available); any Igh mutation (44 available)
Plcg2^Ali5 mutation (0 available); any Plcg2 mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:174233 )

N	• the distribution of B cell subsets in the peritoneal cavity is normal

increased B-1a cell number ( J:174233 )

• compared with Igh^tm1.1Twin homozygotes

hematopoietic system

increased B-1a cell number ( J:174233 )

• compared with Igh^tm1.1Twin homozygotes

Allelic Composition	Plcg2^Ali5/Plcg2⁺ Rag1^tm1Mom/Rag1^tm1Mom
Genetic Background	involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2^Ali5

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcg2^Ali5 mutation (0 available); any Plcg2 mutation (74 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

chronic inflammation ( J:97930 )

• approximately 70% of homozygous mice developed despite absence of B and T cells

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears

skeleton

osteoarthritis ( J:97930 )

• resulting in severe arthritis of the small joints of the paws and missing phalanges

integument

dermatitis ( J:97930 )

• in the superficial layers of the skin of the paws and ears

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