Phenotypes associated with this allele

• Allele Symbol: S1pr5^tm1Club
• Allele Name: targeted mutation 1, Catherine Lubetzki
• Allele ID: MGI:3577728
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	S1pr5^tm1Club/S1pr5^tm1Club	B6.129P2-S1pr5^tm1Club	MGI:5301556
hm2	S1pr5^tm1Club/S1pr5^tm1Club	involves: 129P2/OlaHsd * C57BL/6J	MGI:3578227

Genotype
MGI:5301556

hm1

• Allelic Composition: S1pr5^tm1Club/S1pr5^tm1Club
• Genetic Background: B6.129P2-S1pr5^tm1Club

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal NK cell morphology ( J:178789 )

• mice exhibit reduced mature sinusoidal NK cells exiting from the lymph node and to a lesser extent the bone marrow compared with wild-type mice

decreased NK cell number ( J:178789 )

• in the bone marrow and lymph nodes

abnormal NK cell physiology ( J:178789 )

• NK cells exhibit increased migration to SP1 compared with wild-type cells

hematopoietic system

abnormal NK cell morphology ( J:178789 )

• mice exhibit reduced mature sinusoidal NK cells exiting from the lymph node and to a lesser extent the bone marrow compared with wild-type mice

decreased NK cell number ( J:178789 )

• in the bone marrow and lymph nodes

abnormal NK cell physiology ( J:178789 )

• NK cells exhibit increased migration to SP1 compared with wild-type cells

Genotype
MGI:3578227

hm2

• Allelic Composition: S1pr5^tm1Club/S1pr5^tm1Club
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

nervous system

abnormal oligodendrocyte physiology ( J:98099 )

• sphingosine-1-phosphate, a ligand for Edg8, did not induce retraction of oligodendroglial processes in culture, as it did in wildtype, and did not exhibit any myelin deficiency