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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gzmbtm2Ley
targeted mutation 2, Timothy J Ley
MGI:3577761
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gzmbtm2Ley/Gzmbtm2Ley 129X1/SvJ-Gzmbtm2Ley MGI:3577926


Genotype
MGI:3577926
hm1
Allelic
Composition		 Gzmbtm2Ley/Gzmbtm2Ley
Genetic
Background		 129X1/SvJ-Gzmbtm2Ley
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzmbtm2Ley mutation (0 available); any Gzmb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:96538 )
• displayed a defect in the allogeneic clearance of P815 tumor cells
decreased cytotoxic T cell cytolysis ( J:96538 )
• using a flow-based killing assay, CTLs from mutant mice were significantly less efficient at inducing target cell death at all time point tested

hematopoietic system
decreased cytotoxic T cell cytolysis ( J:96538 )
• using a flow-based killing assay, CTLs from mutant mice were significantly less efficient at inducing target cell death at all time point tested




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory