About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc11a2tm1Nca
targeted mutation 1, Nancy C Andrews
MGI:3577914
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc11a2tm1Nca/Slc11a2tm1Nca 129S6.129S4-Slc11a2tm1Nca MGI:3578656
ht2
 		Slc11a2tm1Nca/Slc11a2+ involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca MGI:3578657
cx3
 		Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca 		involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca MGI:3578659


Genotype
MGI:3578656
hm1
Allelic
Composition		 Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic
Background		 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:98088 )
• by 7 days of age
• RBC transfusions prolong survival

hematopoietic system
decreased hemoglobin content ( J:98088 )
• by 3 days of age
anisocytosis ( J:98088 )
• diminished non-heme iron levels in liver, spleen, kidney, brain and heart
• liver iron levels elevated at birth

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:98088 )
N
• total body iron levels relatively normal

growth/size/body
postnatal growth retardation ( J:98088 )
• progressive postnatal growth retardation
• weigh 30% less than controls by 3 days of age

integument
pallor ( J:98088 )
• at birth




Genotype
MGI:3578657
ht2
Allelic
Composition		 Slc11a2tm1Nca/Slc11a2+
Genetic
Background		 involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased liver iron level ( J:98088 )
• by 8 weeks of age

liver/biliary system
decreased liver iron level ( J:98088 )
• by 8 weeks of age




Genotype
MGI:3578659
cx3
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic
Background		 involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:98088 )
N
• considerably improved survival

homeostasis/metabolism
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age

hematopoietic system
decreased hematocrit ( J:98088 )
• but improved over condition seen in inSlc11a2 knockout mice

growth/size/body
postnatal growth retardation ( J:98088 )
• body weight considerably better than inSlc11a2 knockout mice at 12 weeks of age

liver/biliary system
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory