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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc11a2tm2Nca
targeted mutation 2, Nancy C Andrews
MGI:3577916
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc11a2tm2Nca/Slc11a2tm2Nca
Tg(Vil1-cre)20Syr/? 		involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2 MGI:3578660


Genotype
MGI:3578660
cn1
Allelic
Composition		 Slc11a2tm2Nca/Slc11a2tm2Nca
Tg(Vil1-cre)20Syr/?
Genetic
Background		 involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2tm2Nca mutation (1 available); any Slc11a2 mutation (38 available)
Tg(Vil1-cre)20Syr mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
extramedullary hematopoiesis ( J:98088 )
• sinusoid areas of the liver particularly
• dysplastic erythropoiesis in the spleen
anemia ( J:98088 )
• progressive anemia developed after birth
• profound but not as severe as in knock-out mice
decreased spleen iron level ( J:98088 )
• decreased non-heme iron in the spleen
increased spleen red pulp amount ( J:98088 )
• expanded red pulp

homeostasis/metabolism
decreased heart iron level ( J:98088 )
• decreased non-heme iron in the heart
decreased spleen iron level ( J:98088 )
• decreased non-heme iron in the spleen
decreased brain iron level ( J:98088 )
• diminished non-heme iron levels in the brain
decreased kidney iron level ( J:98088 )
• decreased non-heme iron
decreased liver iron level ( J:98088 )
• decreased non-heme iron in the liver

cardiovascular system
decreased heart iron level ( J:98088 )
• decreased non-heme iron in the heart

immune system
decreased spleen iron level ( J:98088 )
• decreased non-heme iron in the spleen
increased spleen red pulp amount ( J:98088 )
• expanded red pulp

liver/biliary system
decreased liver iron level ( J:98088 )
• decreased non-heme iron in the liver

renal/urinary system
decreased kidney iron level ( J:98088 )
• decreased non-heme iron

nervous system
decreased brain iron level ( J:98088 )
• diminished non-heme iron levels in the brain

growth/size/body
enlarged heart ( J:98088 )
enlarged spleen ( J:98088 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory