Phenotypes associated with this allele

• Allele Symbol: Lias^nehe
• Allele Name: nearly headless
• Allele ID: MGI:3578174
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lias^nehe/Lias^nehe	C3Fe.B6-Lias^nehe	MGI:4830283
hm2	Lias^nehe/Lias^nehe	involves: C3HeB/FeJ * C57BL/6J	MGI:3580697
ht3	Lias^nehe/Lias^tm1Mae	involves: 129S6/SvEvTac * C57BL/6J	MGI:4830284

Genotype
MGI:4830283

hm1

• Allelic Composition: Lias^nehe/Lias^nehe
• Genetic Background: C3Fe.B6-Lias^nehe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:163880 )

• mice survive until E12.5

nervous system

open neural tube ( J:163880 )

• at E9.5

abnormal brain morphology ( J:163880 )

• at E12.5, the anterior brain is truncated compared to in wild-type mice

• marker expression indicates that tissues anterior to the midbrain are absent unlike in wild-type mice

forebrain hypoplasia ( J:163880 )

• marker expression suggests that dorsal forebrain tissue is reduced compared to in wild-type mice

• from the earliest stages, the domain of the forebrain progenitors is reduced compared to in wild-type mice

• however, cell proliferation is normal

telencephalon hypoplasia ( J:163880 )

• nearly absent

embryo

rostral body truncation ( J:163880 )

• mice exhibit anterior truncation compared with wild-type mice

embryonic growth retardation ( J:163880 )

• after the six somite stage, embryonic development is delayed 10 to 12 hours compared to in wild-type mice

open neural tube ( J:163880 )

• at E9.5

abnormal prechordal plate morphology ( J:163880 )

• marker expression reveals defective prechordal plate compared to in wild-type mice

cardiovascular system

dilated heart ( J:163880 )

• at E12.5

growth/size/body

embryonic growth retardation ( J:163880 )

• after the six somite stage, embryonic development is delayed 10 to 12 hours compared to in wild-type mice

microcephaly ( J:163880 )

• at E9.5

Genotype
MGI:3580697

hm2

• Allelic Composition: Lias^nehe/Lias^nehe
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

• die at E10

nervous system

decreased forebrain size ( J:98216 )

• small forebrain

exencephaly ( J:98216 )

Genotype
MGI:4830284

ht3

• Allelic Composition: Lias^nehe/Lias^tm1Mae
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

embryo

rostral body truncation ( J:163880 )

• mice exhibit anterior truncation compared with wild-type mice

embryonic growth retardation ( J:163880 )

• more severe than in Lias^nehe homozygotes

growth/size/body

embryonic growth retardation ( J:163880 )

• more severe than in Lias^nehe homozygotes