Phenotypes associated with this allele

• Allele Symbol: Ajuba^tm1Gdl
• Allele Name: targeted mutation 1, Gregory D Longmore
• Allele ID: MGI:3578221
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ajuba^tm1Gdl/Ajuba^tm1Gdl	involves: 129X1/SvJ * C57BL/6	MGI:3578294

Genotype
MGI:3578294

hm1

• Allelic Composition: Ajuba^tm1Gdl/Ajuba^tm1Gdl
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell migration ( J:98248 )

• homozygous null MEFs displayed a marked inhibition of migration in a scratch-wound repair assay, covering only 20-30% of the wound area compared to complete wound closure in wildtype, however homozygous null mice were viable and reached adulthood without any obvious phenotypes

• migrating homozygous null MEFs exhibited abnormal lamellipodia production with decreased levels and activation of FAK, p130Cas, and Rac1