Analysis Tools
mortality/aging
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• homozygous null mice were underrepresented among littermates at 4 weeks of age and most (though some survived) died soon after birth as a result of cannibalization of the omphalocele by the mother
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vision/eye
blepharitis
(
J:98250
)
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• 50% of the surviving homozygotes gradually developed proliferative inflammation of the eyelid that almost covered the entire eye at 5-6 months of age
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• actin cables that encircle the eye in the epithelial cells of the eyelid were disorganized
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• impaired or delayed extension of the eyelid epithelial sheet resulting in open eyelids from E16.5 to birth
• 50% had fully open eyelids while the rest were almost fully fused but manifested a hole with a diameter of less than 1 mm
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immune system
blepharitis
(
J:98250
)
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• 50% of the surviving homozygotes gradually developed proliferative inflammation of the eyelid that almost covered the entire eye at 5-6 months of age
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growth/size/body
omphalocele
(
J:98250
)
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• 26.5% exhibited severe omphalocele, including the liver and small intestine, 38.2% exhibited moderate omphalocele, with only the small intestine protruding, and 35.3% exhibited mild omphalocele, in which the intestine protrudes upon crying
• omphalocele resulted from an impaired umbilical ring closure due to failure of actin assembly in the epithelium at the site of epidermal ridge formation
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integument
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• only 11 and 20% of homozygous null keratinocytes contained actin bundles at 30 and 120 min after EGF stimulation compared to 33 and 56.4% in wildtype and these actin bundles were thinner and fewer in number
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