Analysis Tools
mortality/aging
|
• at E11.5, the hearts stop beating indicating lethality
|
embryo
|
• hypomorphic
|
|
• at E9.5, mice exhibit a failure to properly rotate the body along the axis compared unlike wild-type mice
|
|
• mice exhibit abnormal anterior-posterior axis patterning compared with wild-type mice
• however, the anterior posterior axis remains intact
|
|
• at E9.5
|
|
• at E9.5 and E10.5
|
|
• disorganized
|
|
• somites are smaller than in wild-type mice
|
craniofacial
|
• mice exhibit clefting of the nasal process unlike wild-type mice
|
|
• hypomorphic
|
cardiovascular system
hemorrhage
(
J:162916
)
|
• in the frontonasal process, cranial folds, and the pharyngeal arches
|
cellular
|
• mouse embryonic fibroblasts exhibit fragmentation of mitochondria unlike in wild-type mice
|
growth/size/body
|
• at E9.5
|
|
• at E9.5 and E10.5
|
nervous system
exencephaly
(
J:162916
)
|
• at E9.5
|
