Phenotypes associated with this allele

• Allele Symbol: Nup133^mermaid
• Allele Name: mermaid
• Allele ID: MGI:3578539
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nup133^mermaid/Nup133^mermaid	involves: 129S1/SvImJ * C57BL/6J	MGI:3802523
hm2	Nup133^mermaid/Nup133^mermaid	involves: C3HeB/FeJ * C57BL/6J	MGI:3580844
ht3	Nup133^Gt(RRK090)Byg/Nup133^mermaid	involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J	MGI:3802522

Genotype
MGI:3802523

hm1

• Allelic Composition: Nup133^mermaid/Nup133^mermaid
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137199 )

• mice die between E9.5 and E10.5

embryo

embryonic growth retardation ( J:137199 )

abnormal neural tube morphology ( J:137199 )

• in chimeric mice, cells fail to contribute to the neural tube

kinked neural tube ( J:137199 )

• mice exhibit a kinked and exencephalic neural tube

abnormal primitive streak morphology ( J:137199 )

• thin and pointed

abnormal somite development ( J:137199 )

• somites segment irregularly

• in chimeric mice, cells fail to contribute to the somite tissues

nervous system

abnormal nervous system development ( J:137199 )

• in culture, embryonic stem cells fail to generate neurons

abnormal neural tube morphology ( J:137199 )

• in chimeric mice, cells fail to contribute to the neural tube

kinked neural tube ( J:137199 )

• mice exhibit a kinked and exencephalic neural tube

exencephaly ( J:137199 )

• mice exhibit a kinked and exencephalic neural tube

growth/size/body

embryonic growth retardation ( J:137199 )

decreased body length ( J:137199 )

cardiovascular system

pericardial edema ( J:137199 )

homeostasis/metabolism

pericardial edema ( J:137199 )

Genotype
MGI:3580844

hm2

• Allelic Composition: Nup133^mermaid/Nup133^mermaid
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:98216 )

embryo

embryonic growth arrest ( J:98216 )

• arrest at E8.5

decreased paraxial mesoderm size ( J:98216 )

• deficit of paraxial mesoderm

Genotype
MGI:3802522

ht3

• Allelic Composition: Nup133^{Gt(RRK090)Byg}/Nup133^mermaid
• Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

embryo

abnormal embryo development ( J:137199 )

• mice exhibit an intermediate phenotype compared to Nup133^mermaid homozygotes