Phenotypes associated with this allele

• Allele Symbol: Ddx11^cetus
• Allele Name: cetus
• Allele ID: MGI:3578542
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddx11^cetus/Ddx11^cetus	either: C3Fe.B6-Ddx11^cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)	MGI:5431356
hm2	Ddx11^cetus/Ddx11^cetus	involves: C3HeB/FeJ * C57BL/6J	MGI:3580847
ht3	Ddx11^cetus/Ddx11^tm1Jiml	involves: 129S/SvEv * C3HeB/FeJ * C57BL/6J	MGI:5431357

Genotype
MGI:5431356

hm1

• Allelic Composition: Ddx11^cetus/Ddx11^cetus
• Genetic Background: either: C3Fe.B6-Ddx11^cetus or (involves: C3HeB/FeJ * C57BL/6J * CAST/Ei)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:185600 )

• all are dead before E10.5

embryo

increased embryonic tissue cell apoptosis ( J:185600 )

• dramatic increase in the number of apoptotic cells in the embryo at E7.5

• apoptotic cells are evenly distributed in the epithelia, mesoderm, and endoderm

embryonic growth arrest ( J:185600 )

• Background Sensitivity: on a congenic C3HHeB/FeJ background 46.9% of embryos arrest at E7.5 compared to only 11.1% in a mixed CAST/Ei background

• some embryos arrest later at E8.5

decreased embryo size ( J:185600 )

• at E8.5

abnormal embryonic tissue morphology ( J:185600 )

• some embryos display blisters at both sides of the midline at E8.5

decreased paraxial mesoderm size ( J:185600 )

• depletion of somitic mesoderm

• however, lateral plate mesoderm appears to be formed normally

open neural tube ( J:185600 )

• at E8.5

kinked neural tube ( J:185600 )

• kinked and/or wavy at E8.5

wavy neural tube ( J:185600 )

• kinked and/or wavy at E8.5

abnormal somite development ( J:185600 )

• in a few embryos somitogenesis appears to be initiated but cells fail to organize into the typical spherical structures characteristic of epithelial somites

absent somites ( J:185600 )

• lack morphologically distinguishable somites at E8.5

• in embryos with blisters, somites are replaced by an area devoid of cells

• in embryos without blisters the surface ectoderm is in direct apposition to the endoderm and lateral plate mesoderm

small allantois ( J:185600 )

• rudimentary

abnormal amniotic cavity morphology ( J:185600 )

• cells abnormally accumulate in the amniotic cavity

failure of chorioallantoic fusion ( J:185600 )

cellular

increased embryonic tissue cell apoptosis ( J:185600 )

• dramatic increase in the number of apoptotic cells in the embryo at E7.5

• apoptotic cells are evenly distributed in the epithelia, mesoderm, and endoderm

cardiovascular system

failure of heart looping ( J:185600 )

• at E8.5

nervous system

open neural tube ( J:185600 )

• at E8.5

kinked neural tube ( J:185600 )

• kinked and/or wavy at E8.5

wavy neural tube ( J:185600 )

• kinked and/or wavy at E8.5

growth/size/body

decreased embryo size ( J:185600 )

• at E8.5

Genotype
MGI:3580847

hm2

• Allelic Composition: Ddx11^cetus/Ddx11^cetus
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

embryo

embryonic growth arrest ( J:98216 )

• early somite stage arrest

decreased paraxial mesoderm size ( J:98216 )

• deficit of paraxial mesoderm

Genotype
MGI:5431357

ht3

• Allelic Composition: Ddx11^cetus/Ddx11^tm1Jiml
• Genetic Background: involves: 129S/SvEv * C3HeB/FeJ * C57BL/6J

embryo

embryonic growth arrest ( J:185600 )

• arrest between E7.5 and E8.5

decreased embryo size ( J:185600 )

absent paraxial mesoderm ( J:185600 )

• absence of somitic mesoderm

kinked neural tube ( J:185600 )

absent somites ( J:185600 )

growth/size/body

decreased embryo size ( J:185600 )

nervous system

kinked neural tube ( J:185600 )