Phenotypes associated with this allele

• Allele Symbol: Notch3^tm1Khan
• Allele Name: targeted mutation 1, Kazunori Hanaoka
• Allele ID: MGI:3578622
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch3^tm1Khan/Notch3^tm1Khan	involves: C57BL/6 * CBA	MGI:3580512

Genotype
MGI:3580512

hm1

• Allelic Composition: Notch3^tm1Khan/Notch3^tm1Khan
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:98284 )

• at 10 weeks, but not at 4 weeks, of age the thymus is smaller compared to age matched wild-type mice

decreased thymocyte number ( J:98284 )

• at 10 weeks, but not at 4 weeks, of age thymocyte numbers are decreased however the distribution of thymocyte subsets is not altered

hematopoietic system

small thymus ( J:98284 )

• at 10 weeks, but not at 4 weeks, of age the thymus is smaller compared to age matched wild-type mice

decreased thymocyte number ( J:98284 )

• at 10 weeks, but not at 4 weeks, of age thymocyte numbers are decreased however the distribution of thymocyte subsets is not altered

endocrine/exocrine glands

small thymus ( J:98284 )

• at 10 weeks, but not at 4 weeks, of age the thymus is smaller compared to age matched wild-type mice

decreased thymocyte number ( J:98284 )

• at 10 weeks, but not at 4 weeks, of age thymocyte numbers are decreased however the distribution of thymocyte subsets is not altered