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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sod2tm1.1Kskk
targeted mutation 1.1, Karin Scharffetter-Kochanek
MGI:3578627
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sod2tm1.1Kskk/Sod2tm1.1Kskk involves: 129P2/OlaHsd * C57BL/6 MGI:3580872
ht2
Sod2tm1.1Kskk/Sod2+ involves: 129P2/OlaHsd * C57BL/6 MGI:3580873


Genotype
MGI:3580872
hm1
Allelic
Composition
Sod2tm1.1Kskk/Sod2tm1.1Kskk
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sod2tm1.1Kskk mutation (0 available); any Sod2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die 8 -10 days after birth

cardiovascular system
• extensive lipid peroxidation is seen in the myocardium at 3 days after birth

growth/size/body
• severe growth retardation

behavior/neurological
• fatigue rapidly

cellular
• extensive lipid peroxidation is seen in the myocardium at 3 days after birth

muscle
• extensive lipid peroxidation is seen in the myocardium at 3 days after birth




Genotype
MGI:3580873
ht2
Allelic
Composition
Sod2tm1.1Kskk/Sod2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sod2tm1.1Kskk mutation (0 available); any Sod2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age
• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age

cellular
• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells
• clusters of cardiomyocytes show signs of lipid peroxidation in 7 out of 10 heterozygotes at 10 days of age
• increased formation of nitrotyrosine is seen in the myocardium of 3 and 10 day old heterozygotes

muscle
• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age
• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age
• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory