About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igh-VB1-8/Igh-6m)1Mjsk
transgene insertion 1, Mark J Shlomchik
MGI:3578639
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-VB1-8/Igh-6m)1Mjsk/? 		NODCaj.Cg-Ighmtm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ MGI:3581965


Genotype
MGI:3581965
cx1
Allelic
Composition		 Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-VB1-8/Igh-6m)1Mjsk/?
Genetic
Background		 NODCaj.Cg-Ighmtm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Tg(Igh-VB1-8/Igh-6m)1Mjsk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:93190 )
• female Igh-6-deficient transgenic mice show a 7-fold increase in the incidence of (blood glucose >250 mg/dl) diabetes compared with nontransgenic littermates

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:93190




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory