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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfge8Gt(KST227)Byg
gene trap KST227, BayGenomics
MGI:3578644
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg B6.129P2-Mfge8Gt(KST227)Byg MGI:3578949
hm2
 		Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3623586


Genotype
MGI:3578949
hm1
Allelic
Composition		 Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic
Background		 B6.129P2-Mfge8Gt(KST227)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8Gt(KST227)Byg mutation (3 available); any Mfge8 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

immune system
impaired macrophage phagocytosis ( J:98314 )
• apoptotic cell phagocytosis by macrophages is reduced
enlarged spleen ( J:98314 )
• the spleen is enlarged and apoptotic cells accumulate in the spleen

cardiovascular system
abnormal physiological neovascularization ( J:98314 )
• in a surgically induced ischemic hindlimb model VEGFA treatment does not stimulate neovessel formation in mutants unlike in wild-type mice; however FGF2 treatment stimulates neovessel formation in both mutant and wild-type mice
• neovascularization of implanted matrigel is reduced in VEGFA-treated homozygotes compared to wild-type mice; however, embryonic vascular development is normal

renal/urinary system
abnormal kidney physiology ( J:98314 )
• in aging homozygotes, immunoglobulin deposits are seen in the kidney

hematopoietic system
impaired macrophage phagocytosis ( J:98314 )
• apoptotic cell phagocytosis by macrophages is reduced
enlarged spleen ( J:98314 )
• the spleen is enlarged and apoptotic cells accumulate in the spleen

growth/size/body
enlarged spleen ( J:98314 )
• the spleen is enlarged and apoptotic cells accumulate in the spleen

cellular
impaired macrophage phagocytosis ( J:98314 )
• apoptotic cell phagocytosis by macrophages is reduced




Genotype
MGI:3623586
hm2
Allelic
Composition		 Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8Gt(KST227)Byg mutation (3 available); any Mfge8 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

immune system
impaired macrophage phagocytosis ( J:107106 )
• impaired engulfment of apoptotic thymocytes
mastitis ( J:107106 )
• inflammation of the mammary glands is seen by day 4 of involution
enlarged spleen ( J:107106 )
• age dependent splenomegaly

hematopoietic system
impaired macrophage phagocytosis ( J:107106 )
• impaired engulfment of apoptotic thymocytes
enlarged spleen ( J:107106 )
• age dependent splenomegaly

endocrine/exocrine glands
abnormal involution of the mammary gland ( J:107106 )
• on the first and second days of involution increased apoptotic bodies are seen in the alveolar lumens and alveolar collapse and fat cell repopulation are delayed; however no increase in the number of apoptotic cells in the epithelium is seen
• engulfment of apoptotic cells by alveolar epithelial cells is reduced
abnormal mammary gland duct morphology ( J:107106 )
• at 4 weeks of age ducts appear normal but by 8 weeks dilation and distension of the ducts is seen in some homozygotes
• progressive ductal dilation of the primary, secondary, and tertiary ducts is seen with repeated pregnancies; however duct diameter is similar to wild-type in 9 month old virgin mice
mastitis ( J:107106 )
• inflammation of the mammary glands is seen by day 4 of involution

integument
abnormal involution of the mammary gland ( J:107106 )
• on the first and second days of involution increased apoptotic bodies are seen in the alveolar lumens and alveolar collapse and fat cell repopulation are delayed; however no increase in the number of apoptotic cells in the epithelium is seen
• engulfment of apoptotic cells by alveolar epithelial cells is reduced
abnormal mammary gland duct morphology ( J:107106 )
• at 4 weeks of age ducts appear normal but by 8 weeks dilation and distension of the ducts is seen in some homozygotes
• progressive ductal dilation of the primary, secondary, and tertiary ducts is seen with repeated pregnancies; however duct diameter is similar to wild-type in 9 month old virgin mice
mastitis ( J:107106 )
• inflammation of the mammary glands is seen by day 4 of involution

growth/size/body
enlarged spleen ( J:107106 )
• age dependent splenomegaly

cellular
impaired macrophage phagocytosis ( J:107106 )
• impaired engulfment of apoptotic thymocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory