Phenotypes associated with this allele

• Allele Symbol: Elf5^tm1Plp
• Allele Name: targeted mutation 1, Peter L Pfeffer
• Allele ID: MGI:3578666
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elf5^tm1Plp/Elf5^tm1Plp	involves: 129S1/Sv * 129X1/SvJ	MGI:3578820
hm2	Elf5^tm1Plp/Elf5^tm1Plp	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:3578822

Genotype
MGI:3578820

hm1

• Allelic Composition: Elf5^tm1Plp/Elf5^tm1Plp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98382 )

• all homozygous embryos die between E8.5 and E9.5

• tetraploid rescued homozygous embryos can survive and develop normally to E10.5

• Background Sensitivity: embryonic death is earlier compared to embryos on a background that includes BALB/c

embryo

abnormal ectoderm development ( J:98382 )

• at E8.5 embryos consist of a sac of ectoderm that is frequently still proliferating with folding of the excess epithelium

• the ectoderm displays anterior neuroectodermal characteristics and expression of genes normally expressed in the posterior ectoderm is missing

decreased embryo size ( J:98382 )

• embryo size is severely reduced at E8.5

absent mesoderm ( J:98382 )

• at E7.5 mesoderm has failed to form and the embryos still resemble egg cylinders

• at E8.5 about half of the embryos still lack mesoderm

abnormal mesenchyme morphology ( J:98382 )

• at E8.5 about half of the embryos contain a mass of mesenchymal cells at the proximal end of the embryo

abnormal trophoblast giant cell morphology ( J:98382 )

• the trophoblast stem cells are not maintained

absent chorion ( J:98382 )

• the chorion fails to form

absent extraembryonic ectoderm ( J:98382 )

• embryos implant normally but the extraembryonic ectoderm fails to form

• the lack of extraembryonic ectoderm can be seen at the pregastrula stage

growth/size/body

decreased embryo size ( J:98382 )

• embryo size is severely reduced at E8.5

Genotype
MGI:3578822

hm2

• Allelic Composition: Elf5^tm1Plp/Elf5^tm1Plp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98382 )

• some developmentally delayed embryos can still be found at E10.5; however all homozygous embryos are dead by E12.5

• Background Sensitivity: embryonic death is delayed compared to embryos on a 129 background

embryo

embryonic growth retardation ( J:98382 )

• at E10.5 surviving embryos resemble those at E7.5 or E8.5

growth/size/body

embryonic growth retardation ( J:98382 )

• at E10.5 surviving embryos resemble those at E7.5 or E8.5