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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abcg2tm1Bsor
targeted mutation 1, Brian P Sorrentino
MGI:3578727
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Abcg2tm1Bsor/Abcg2tm1Bsor involves: 129P2/OlaHsd * C57BL/6 MGI:3579988


Genotype
MGI:3579988
hm1
Allelic
Composition		 Abcg2tm1Bsor/Abcg2tm1Bsor
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg2tm1Bsor mutation (0 available); any Abcg2 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:98134 )
• significant reduction in the number of side population cells in the bone marrow and in skeletal muscle

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:98134 )
• hematopoietic cells from mutant mice were significantly more sensitive to mitoxantrone in drug-treated transplanted mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory