All Phenotypes Tnf<tm2Jods> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnf^tm2Jods/Tnf^tm2Jods	C57BL/6-Tnf^tm2Jods	MGI:3582931
hm2	Tnf^tm2Jods/Tnf^tm2Jods	involves: C57BL/6	MGI:3582923
hm3	Tnf^tm2Jods/Tnf^tm2Jods	involves: C57BL/6 * C57BL/6J	MGI:4867651

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal spleen white pulp morphology ( J:98591 )

• some loss of B and T cell area segregation, however less than seen in homozygous Tnf^tm1Jods mice

abnormal metallophilic macrophage morphology ( J:98591 )

• the MOMA-1⁺ marginal zone metallophilic macrophages did not form a completely continuous cell layer

abnormal spleen follicular dendritic cell network ( J:98591 )

• follicular dendritic cell networks were undetectable in unimmunized homozygous mutant mice

• size and frequency of the formation CR1⁺ follicular dendritic networks upon immunization was substantially less than in wild-type

abnormal spleen primary B follicle morphology ( J:98591 )

• absent primary B cell follicles

decreased spleen germinal center number ( J:98591 )

• frequency of the formation of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

decreased spleen germinal center size ( J:98591 )

• size of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

abnormal Peyer's patch follicle morphology ( J:98591 )

• imperfect primary B cell follicles, however separation of T and B cell regions was fairly normal

abnormal lymph node primary follicle morphology ( J:98591 )

abnormal immune system physiology ( J:98591 )

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:98591 )

• reduced severity of experimental autoimmune encephalomyelitis (EAE) under suboptimal immunization conditions relative to wild-type, with less inflammation in the spinal cord and the majority of homozygous mutant mice recovering rapidly

decreased susceptibility to endotoxin shock ( J:98591 )

• resistant to endotoxic shock induced by low doses of LPS, however at high doses, started to show signs of shock and 2/5 mice succumbed to shock, however with a delayed time of death compared to wild-type

hematopoietic system

abnormal spleen white pulp morphology ( J:98591 )

• some loss of B and T cell area segregation, however less than seen in homozygous Tnf^tm1Jods mice

abnormal metallophilic macrophage morphology ( J:98591 )

• the MOMA-1⁺ marginal zone metallophilic macrophages did not form a completely continuous cell layer

abnormal spleen follicular dendritic cell network ( J:98591 )

• follicular dendritic cell networks were undetectable in unimmunized homozygous mutant mice

• size and frequency of the formation CR1⁺ follicular dendritic networks upon immunization was substantially less than in wild-type

abnormal spleen primary B follicle morphology ( J:98591 )

• absent primary B cell follicles

decreased spleen germinal center number ( J:98591 )

• frequency of the formation of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

decreased spleen germinal center size ( J:98591 )

• size of PNA⁺ germinal centers upon immunization was substantially less than in wild-type

Allelic Composition	Tnf^tm2Jods/Tnf^tm2Jods
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnf^tm2Jods mutation (1 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:127028 )

• mutants control parasite replication as effectively as infected wild-type C57Bl/6 60 days following infection with L.major

• neutrophil numbers are similar in uninfected or infected (during first days of infection) wild-type controls and Tnf-null mice; levels after 7 days are similar to infected controls

• lymph node cells secrete similar levels of IFN-gamma to cells from infected wild-type; upon L. major re-stimulation, similar levels of Il-4 are released

• number of parasitized neutrophils in lesion is similar to infected controls at 4 hours after i.p. injection of L. major; percentage of proliferating parasites released from neutrophils is similar to infected controls

decreased immunoglobulin level ( J:127028 )

• levels of IgG2a in sera are lower than in infected wild-type controls

abnormal lymph node cell ratio ( J:127028 )

• number of IFN-gamma secreting CD4+ T cells is slightly but significantly increased in draining lymph nodes compared to infected wild-type C57BL/6

increased susceptibility to bacterial infection ( J:98170 )

• initially, were able to contain M. tuberculosis growth to a similar extent as wild-type, however were unable to control infection long term (after about 12 weeks), showed more diffuse lesions and increased neurtrophil infiltrate than in wild-type and had a mean time of death at 170 days

hematopoietic system

decreased immunoglobulin level ( J:127028 )

• levels of IgG2a in sera are lower than in infected wild-type controls

Allelic Composition	Tnf^tm2Jods/Tnf^tm2Jods
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnf^tm2Jods mutation (1 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased liver free fatty acids level ( J:112797 )

• when fed a high cholesterol diet

liver/biliary system

decreased liver free fatty acids level ( J:112797 )

• when fed a high cholesterol diet

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24