Analysis Tools|
Allele Symbol Allele Name Allele ID |
H1f6tm1Drab targeted mutation 1, Birgit Drabent MGI:3578782 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous null mice develop normally and exhibit normal testicular morphology, spermatogenesis and fertility, although Hist1h1a (H1.1), Hist1h1c (H1.2) and Hist1h1e (H1.4) gene expression was enhanced during spermatogenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice
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• produced no offspring when mated to wild-type females
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• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
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• impaired sperm penetration of zona pellucida from wild-type females
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fertility of males is reduced to 20%-50% of controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
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• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
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• litter size was sharply reduced when mutant males were mated to wild-type females
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• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
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• reduced binding of sperm to zona pellucida from wild-type females
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• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
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• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
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• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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