Phenotypes associated with this allele

• Allele Symbol: Irf8^myls
• Allele Name: myeloproliferative syndrome
• Allele ID: MGI:3578920
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf8^myls/Irf8^myls	involves: BALB/cJ * BXH2/TyJ-Irf8^myls	MGI:3578959
ht2	Irf8^myls/Irf8^+	involves: BXH2/TyJ * C57BL/6	MGI:4939596
cx3	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	BXH2/TyJ	MGI:3578951
cx4	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: A/J * BXH2/TyJ	MGI:3578958
cx5	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s	involves: BALB/cJ * BXH2/TyJ	MGI:3578955
cx6	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: BALB/cJ * BXH2/TyJ	MGI:3578956
cx7	Irf8^myls/Irf8^myls Slc11a1^s/Slc11a1^s	involves: BALB/cJ * BXH2/TyJ	MGI:3578954
cx8	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: BXH2/TyJ * C3H/HeJ	MGI:3578957
cx9	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r	involves: BXH2/TyJ * C57BL/6J	MGI:3578953
cx10	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s	involves: BXH2/TyJ * C57BL/6J	MGI:3578952

Genotype
MGI:3578959

hm1

• Allelic Composition: Irf8^myls/Irf8^myls
• Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8^myls

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:97931 )

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system

enlarged spleen ( J:97931 )

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

growth/size/body

enlarged spleen ( J:97931 )

Genotype
MGI:4939596

ht2

• Allelic Composition: Irf8^myls/Irf8⁺
• Genetic Background: involves: BXH2/TyJ * C57BL/6

immune system

increased B cell number ( J:168923 )

increased transitional stage B cell number ( J:168923 )

increased B-1b cell number ( J:168923 )

increased follicular B cell number ( J:168923 )

hematopoietic system

increased B cell number ( J:168923 )

increased transitional stage B cell number ( J:168923 )

increased B-1b cell number ( J:168923 )

increased follicular B cell number ( J:168923 )

Genotype
MGI:3578951

cx3

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^r
• Genetic Background: BXH2/TyJ

mortality/aging

premature death ( J:97931 )

• die within 10 months of age

immune system

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

decreased interferon-gamma secretion ( J:97931 )

• splenocytes did not secrete IFN-gamma in response to LPS treatment

decreased interleukin-12 secretion ( J:97931 )

• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

neoplasm

increased chronic myelocytic leukemia incidence ( J:97931 )

• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

growth/size/body

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:97931

Genotype
MGI:3578958

cx4

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^r
• Genetic Background: involves: A/J * BXH2/TyJ

mortality/aging

premature death ( J:97931 )

• die within 10 months of age

neoplasm

increased chronic myelocytic leukemia incidence ( J:97931 )

• develop fatal leukemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:97931

Genotype
MGI:3578955

cx5

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^s
• Genetic Background: involves: BALB/cJ * BXH2/TyJ

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Genotype
MGI:3578956

cx6

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^r
• Genetic Background: involves: BALB/cJ * BXH2/TyJ

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Genotype
MGI:3578954

cx7

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^s/Slc11a1^s
• Genetic Background: involves: BALB/cJ * BXH2/TyJ

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Genotype
MGI:3578957

cx8

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^r
• Genetic Background: involves: BXH2/TyJ * C3H/HeJ

immune system

enlarged spleen ( J:97931 )

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

hematopoietic system

enlarged spleen ( J:97931 )

growth/size/body

enlarged spleen ( J:97931 )

Genotype
MGI:3578953

cx9

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^r
• Genetic Background: involves: BXH2/TyJ * C57BL/6J

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Genotype
MGI:3578952

cx10

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^s
• Genetic Background: involves: BXH2/TyJ * C57BL/6J

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection