Phenotypes associated with this allele

• Allele Symbol: Lax1^tm1Wz
• Allele Name: targeted mutation 1, Weiguo Zhang
• Allele ID: MGI:3579135
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lax1^tm1Wz/Lax1^tm1Wz	involves: C57BL/6	MGI:3583207

Genotype
MGI:3583207

hm1

• Allelic Composition: Lax1^tm1Wz/Lax1^tm1Wz
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:98403 )

• increased calcium flux after stimulation with anti-IgM antibodies

immune system

abnormal spleen germinal center morphology ( J:98403 )

• spontaneous germinal center formation in naive homozygous null mice although showed no signs of autoimmune disease

abnormal splenic cell ratio ( J:98403 )

• increased percentage of CD23^-IgM⁺ cells in the spleen, likely resulting from a decrease in CD23 (Fcer2a) expression

abnormal B cell physiology ( J:98403 )

• B cells were hypersensitive and showed reduced cell death, increased calcium flux, increased tyrosine phosphorylation, and increased p38 MAPK and Akt activation after stimulation with anti-IgM antibodies, however lymphocyte development was normal

abnormal B cell calcium ion homeostasis ( J:98403 )

• increased calcium flux after stimulation with anti-IgM antibodies

increased IgE level ( J:98403 )

• IgE levels were about 8 times higher than in wild-type

increased IgG1 level ( J:98403 )

• IgG1 levels were 2-3 fold higher than in wild-type

increased IgG2a level ( J:98403 )

• IgG2a levels were 2-3 fold higher than in wild-type

abnormal T cell physiology ( J:98403 )

• T cells were hypersensitive when activated with anti-CD3 and CD28 antibodies, producing increased levels of IL-2 and showing reduced cell death

abnormal T cell activation ( J:98403 )

• enhanced T cell activation as evidenced by increased calcium flux, tyrosine phosphorylation, p38 MAPK and Akt activation, and enhanced cell survival upon engagement of AgRs

hematopoietic system

abnormal spleen germinal center morphology ( J:98403 )

• spontaneous germinal center formation in naive homozygous null mice although showed no signs of autoimmune disease

abnormal splenic cell ratio ( J:98403 )

• increased percentage of CD23^-IgM⁺ cells in the spleen, likely resulting from a decrease in CD23 (Fcer2a) expression

abnormal B cell physiology ( J:98403 )

• B cells were hypersensitive and showed reduced cell death, increased calcium flux, increased tyrosine phosphorylation, and increased p38 MAPK and Akt activation after stimulation with anti-IgM antibodies, however lymphocyte development was normal

abnormal B cell calcium ion homeostasis ( J:98403 )

• increased calcium flux after stimulation with anti-IgM antibodies

increased IgE level ( J:98403 )

• IgE levels were about 8 times higher than in wild-type

increased IgG1 level ( J:98403 )

• IgG1 levels were 2-3 fold higher than in wild-type

increased IgG2a level ( J:98403 )

• IgG2a levels were 2-3 fold higher than in wild-type

abnormal T cell physiology ( J:98403 )

• T cells were hypersensitive when activated with anti-CD3 and CD28 antibodies, producing increased levels of IL-2 and showing reduced cell death

abnormal T cell activation ( J:98403 )

• enhanced T cell activation as evidenced by increased calcium flux, tyrosine phosphorylation, p38 MAPK and Akt activation, and enhanced cell survival upon engagement of AgRs