Phenotypes associated with this allele

• Allele Symbol: Il18rap^tm1Yeh
• Allele Name: targeted mutation 1, Wen-Chen Yeh
• Allele ID: MGI:3579137
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il18rap^tm1Yeh/Il18rap^tm1Yeh	Not Specified	MGI:3583017

Genotype
MGI:3583017

hm1

• Allelic Composition: Il18rap^tm1Yeh/Il18rap^tm1Yeh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte physiology ( J:98417 )

• Il-18-induced NK cytotoxicity and IL-18-induced activation of neutrophils was impaired

• splenocytes and Th1 cells failed to produce IFN-gamma in response to IL-18 alone or IL-18 with IL-12, neutrophils failed to produce IL-6 in response to IL-18, and splenocytes failed to proliferate in response to IL-18 or IL-18 and IL-12

abnormal cytokine secretion ( J:98417 )

• splenocytes and Th1 cells failed to produce IFN-gamma in response to IL-18 alone or IL-18 with IL-12, and neutrophils failed to produce IL-6 in response to IL-18

hematopoietic system

abnormal leukocyte physiology ( J:98417 )

• Il-18-induced NK cytotoxicity and IL-18-induced activation of neutrophils was impaired

• splenocytes and Th1 cells failed to produce IFN-gamma in response to IL-18 alone or IL-18 with IL-12, neutrophils failed to produce IL-6 in response to IL-18, and splenocytes failed to proliferate in response to IL-18 or IL-18 and IL-12