Phenotypes associated with this allele

• Allele Symbol: Lpar3^tm1Jch
• Allele Name: targeted mutation 1, Jerold Chun
• Allele ID: MGI:3579139
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lpar3^tm1Jch/Lpar3^tm1Jch	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3579500

Genotype
MGI:3579500

hm1

• Allelic Composition: Lpar3^tm1Jch/Lpar3^tm1Jch
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

long gestation period ( J:98434 )

♀ • significant prolongation of pregnancy (20.9 days versus 19.4 days in wildtype), however observed no differences in superovulation, fertilization or decidualization

delayed embryo implantation ( J:98434 )

♀ • homozygous null females exhibited delayed implantation, with implantation sites detectable at E5.5 but not at E4.5

impaired embryo implantation ( J:98434 )

♀ • reduced number of implantation sites even though comparable numbers of blastocysts were available for implantation

impaired spacing of implantation sites ( J:98434 )

♀ • implantation sites in homozygous null uteri were crowded/clustered in the uterine segments proximal to the cervix with 44% of implantation sites containing 2-4 embryos at E10.5

decreased litter size ( J:98434 )

• homozygous null females produced litter sizes of less than 50% compared with wildtype

• E10.5 and E18.5 embryos from homozygous null females were smaller than wildtype, while newborns (at P0) were heavier, possibly resulting from prolonged pregnancy and/or smaller litter size

embryo

abnormal placenta morphology ( J:98434 )

• 28% of placentas were shared by two to three embryos at E18.5

• placental hypertrophy

homeostasis/metabolism

decreased prostaglandin level ( J:98434 )

• reduced production of PGE2 and PGI2 in uterus during early pregnancy (E3.5) due to significantly reduced levels of COX2 mRNA

• treatment of pregnant homozygous null females (at E3.5) with exogenous PGE2 or PGI2 rescued the delayed implantation defect but not the uneven embryo spacing or the reduction in implantation sites