Analysis Tools
behavior/neurological
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• trained mutant mice remain on rotarod longer than trained wild type at 5, 10, and 15 rpm, but 20 rpm and spend less time "distracted" while on the rod
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Allele Symbol Allele Name Allele ID |
Park7tm1Shn targeted mutation 1, Jie Shen MGI:3579140 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Characterization of Park7tm1Shn/Park7tm1Shn mice
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• trained mutant mice remain on rotarod longer than trained wild type at 5, 10, and 15 rpm, but 20 rpm and spend less time "distracted" while on the rod
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no inclusions are detected in the substantia nigra or in noradrengeric neurons of the locus coeruleus
• brain histology reveals no abnormal morphology in substantia nigra, striatum or astrocytes in 24-27 month old mice
• dopaminergic or noradrenergic neuron loss is not detected
• striatal dopamine levels are similar to control
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• nigral neurons (dopaminergic neurons) exhibited increased action potential frequency in response to dopamine, indicating a much shorter response to dopamine than in wildtype
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• long term depression was absent in medium spiny neurons, however long term potentiation and cortically-evoked excitatory postsynaptic potentials were normal
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• evoked dopamine overflow in the striatum was reduced, primarily as a result of increased dopamine uptake, however had normal numbers of nigral dopaminergic neurons
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| N |
• performance on the rotarod and in acoustic startle response is similar to control
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• 18-25 month old mice exhibit fewer instances of stereotyped behavior in an open field test as compared to controls
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• 18-25 month old mice exhibit decreased horizontal activity in an open field test as compared to controls
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• reduced vertical activity and time spent rearing at 3 months of age
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• marked reduction in horizontal activity and the time spent moving and had fewer instances of stereotyped behavior at 3 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease 7 | DOID:0060370 |
OMIM:606324 |
J:98436 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased latency to fall (rotarod test) observed at 12 and 18 months of age as compared to controls
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• striatal dopamine levels are significantly elevated at 6, 12 and 18 months of age, however, dopamine turnover is similar to controls
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• striatal serotonin levels are increased at 12 months of age, however, serotonin turnover is similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased latency to fall (rotarod test) observed at 6, 12, 13, 16 and 18 months of age as compared to controls
• trained mutant mice remain on rotarod longer than trained wild type at all speeds tested (5, 10, 15 and 20 rpm) and spend less time "distracted" while on the rod
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• striatal serotonin levels are increased at 12 and 18 months of age
• hippocampal serotonin levels are increased in 15 months old mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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