All Phenotypes Park7<tm1Shn> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Park7^tm1Shn/Park7^tm1Shn
Genetic Background	B6.Cg-Park7^tm1Shn/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7^tm1Shn mutation (2 available); any Park7 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Characterization of Park7^tm1Shn/Park7^tm1Shn mice

behavior/neurological

impaired coordination ( J:202221 )

• trained mutant mice remain on rotarod longer than trained wild type at 5, 10, and 15 rpm, but 20 rpm and spend less time "distracted" while on the rod

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:134518 )

• brain histology reveals no abnormal morphology in substantia nigra, striatum or astrocytes in 24-27 month old mice

• dopaminergic or noradrenergic neuron loss is not detected

• striatal dopamine levels are similar to control

• no inclusions are detected in the substantia nigra or in noradrengeric neurons of the locus coeruleus

abnormal action potential ( J:98436 )

• nigral neurons (dopaminergic neurons) exhibited increased action potential frequency in response to dopamine, indicating a much shorter response to dopamine than in wildtype

absent long-term depression ( J:98436 )

• long term depression was absent in medium spiny neurons, however long term potentiation and cortically-evoked excitatory postsynaptic potentials were normal

abnormal neurotransmitter uptake ( J:98436 )

• evoked dopamine overflow in the striatum was reduced, primarily as a result of increased dopamine uptake, however had normal numbers of nigral dopaminergic neurons

behavior/neurological

behavior/neurological phenotype ( J:134518 )

N	• performance on the rotarod and in acoustic startle response is similar to control

abnormal stationary movement ( J:134518 )

• 18-25 month old mice exhibit fewer instances of stereotyped behavior in an open field test as compared to controls

abnormal locomotor activation ( J:134518 )

• 18-25 month old mice exhibit decreased horizontal activity in an open field test as compared to controls

decreased vertical activity ( J:98436 )

• reduced vertical activity and time spent rearing at 3 months of age

bradykinesia ( J:98436 )

• marked reduction in horizontal activity and the time spent moving and had fewer instances of stereotyped behavior at 3 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 7		DOID:0060370	OMIM:606324	J:98436

Allelic Composition	Gpx1^tm1Ysh/Gpx1^tm1Ysh Prkn^tm1Shn/Prkn^tm1Shn Park7^tm1Shn/Park7^tm1Shn
Genetic Background	B6.Cg-Park7^tm1Shn Gpx1^tm1Ysh Prkn^tm1Shn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1^tm1Ysh mutation (2 available); any Gpx1 mutation (21 available)
Park7^tm1Shn mutation (2 available); any Park7 mutation (56 available)
Prkn^tm1Shn mutation (3 available); any Prkn mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:202221 )

• increased latency to fall (rotarod test) observed at 12 and 18 months of age as compared to controls

homeostasis/metabolism

increased dopamine level ( J:202221 )

• striatal dopamine levels are significantly elevated at 6, 12 and 18 months of age, however, dopamine turnover is similar to controls

increased serotonin level ( J:202221 )

• striatal serotonin levels are increased at 12 months of age, however, serotonin turnover is similar to controls

Allelic Composition	Prkn^tm1Shn/Prkn^tm1Shn Park7^tm1Shn/Park7^tm1Shn
Genetic Background	B6.Cg-Park7^tm1Shn Prkn^tm1Shn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7^tm1Shn mutation (2 available); any Park7 mutation (56 available)
Prkn^tm1Shn mutation (3 available); any Prkn mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:202221 )

• increased latency to fall (rotarod test) observed at 6, 12, 13, 16 and 18 months of age as compared to controls

• trained mutant mice remain on rotarod longer than trained wild type at all speeds tested (5, 10, 15 and 20 rpm) and spend less time "distracted" while on the rod

homeostasis/metabolism

increased serotonin level ( J:202221 )

• striatal serotonin levels are increased at 12 and 18 months of age

• hippocampal serotonin levels are increased in 15 months old mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24