Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-VEGFC)#Pepr
• Allele Name: transgene insertion, Michael S Pepper
• Allele ID: MGI:3579151
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Palm^tm1.2Kili/Palm^tm1.2Kili Tg(RIP1-Tag)2Dh/0 Tg(Ins2-VEGFC)#Pepr/0	involves: C57BL/6J * C57BL/6N * DBA/2J	MGI:7621643
cx2	Palm^tm1.2Kili/Palm^tm1.2Kili Tg(Ins2-VEGFC)#Pepr/0	involves: C57BL/6N	MGI:7621642

Genotype
MGI:7621643

cx1

• Allelic Composition: Palm^tm1.2Kili/Palm^tm1.2Kili; Tg(RIP1-Tag)2Dh/0; Tg(Ins2-VEGFC)#Pepr/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphangiogenesis ( J:237034 )

• 12-week-old mice show a significant decrease in the Lyve-1+ lymphatic coverage of pancreatic tumors relative to double transgenic mice that are wild-type for Palm, indicating impaired tumor-associated lymphangiogenesis

• however, no changes in the number of pancreatic tumors, tumor volume, or intratumoral CD31+ blood microvessel density are observed relative to double transgenic mice wild-type for Palm

Genotype
MGI:7621642

cx2

• Allelic Composition: Palm^tm1.2Kili/Palm^tm1.2Kili; Tg(Ins2-VEGFC)#Pepr/0
• Genetic Background: involves: C57BL/6N

immune system

abnormal lymphangiogenesis ( J:237034 )

• 4-week-old mice show an increase in peri-insular lymphangiogenesis and Lyve-1+ lymphatic vessel density in the periphery of islets of Langerhans that is comparable to that seen in non-tumorigenic Tg(Ins2-VEGFC)#Pepr transgenic mice, consistent with de novo lymphangiogenesis

• however, no increase in CD31+ blood microvessel density is observed within islets, similar to Tg(Ins2-VEGFC)#Pepr mice, suggesting normal angiogenesis