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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plxna4tm1Matl
targeted mutation 1, Marc Tessier-Lavigne
MGI:3579185
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plxna4tm1Matl/Plxna4tm1Matl either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) MGI:3579475
hm2
 		Plxna4tm1Matl/Plxna4tm1Matl involves: 129P2/OlaHsd MGI:5007632
cx3
 		Plxna3tm1Matl/Y
Plxna4tm1Matl/Plxna4tm1Matl 		either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1) MGI:3579482
cx4
 		Plxna3tm1Matl/Plxna3tm1Matl
Plxna4tm1Matl/Plxna4tm1Matl 		either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1) MGI:3590677
cx5
 		Plxna4tm1Matl/Plxna4+
Sema6aGt(KST069)Byg/Sema6a+ 		involves: 129P2/OlaHsd MGI:5007634


Genotype
MGI:3579475
hm1
Allelic
Composition		 Plxna4tm1Matl/Plxna4tm1Matl
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna4tm1Matl mutation (2 available); any Plxna4 mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:98440 )
• repulsive effect of Sema3A on axon growth from sensory neurons from the dorsal root ganglia was reduced compared to wildtype, with 10-20% of axons not repelled at all while the remaining axons were repelled but they fanned out broadly instead of being tightly fasciculated as in wildtype
• repulsive response of superior cervical ganglion neurons to Sema3A, but not Sema3F, was partially reduced
decreased anterior commissure size ( J:98440 )
• anterior commissure tract was reduced in size and defasciculated
abnormal sensory neuron innervation pattern ( J:98440 )
• the spinal sensory axons failed to form thick nerve bundles at E11.5 and showed enhanced branching at E12.5 in the limb buds
• observed a misprojecting fiber bundle along the ventral part of the paw
abnormal trigeminal nerve morphology ( J:98440 )
• disorganized ophthalmic and maxillary projections with the ophthalmic branch overshooting beyond the normal area and some fibers leaving the main bundle to grow in different directions at E11.5, however all three projections of the trigeminal ganglion generally projected to their correct targets

cellular
abnormal axon guidance ( J:98440 )
• repulsive effect of Sema3A on axon growth from sensory neurons from the dorsal root ganglia was reduced compared to wildtype, with 10-20% of axons not repelled at all while the remaining axons were repelled but they fanned out broadly instead of being tightly fasciculated as in wildtype
• repulsive response of superior cervical ganglion neurons to Sema3A, but not Sema3F, was partially reduced




Genotype
MGI:5007632
hm2
Allelic
Composition		 Plxna4tm1Matl/Plxna4tm1Matl
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna4tm1Matl mutation (2 available); any Plxna4 mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neurite morphology ( J:172268 )
• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice
• calbindin+ cells extend processes into the S4/S5 sublamina of the IPL of the retina and exhibit abnormal arborization unlike in wild-type mice
• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice
• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites
• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization and neurite fasciculation of retinal cells types is normal
abnormal amacrine cell morphology ( J:172268 )
• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice
abnormal retina ganglion cell morphology ( J:172268 )
• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice
• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites
• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization

vision/eye
abnormal amacrine cell morphology ( J:172268 )
• dopaminergic amacrine cells extend aberrant processes into the S4/S5 sublamina of the inner plexiform layer unlike in wild-type mice
abnormal retina ganglion cell morphology ( J:172268 )
• M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) exhibit aberrant dendritic arborization in the S4/S5 sublamina of the inner plexiform layer (IPL) and stratification within S1 of the IPL unlike in wild-type mice
• aberrant dopaminergic amacrine cell processes co-localize with M1-type ipRGC dendrites
• however, other subtypes of retinal ganglion and amacrine cells exhibit normal neurite arborization




Genotype
MGI:3579482
cx3
Allelic
Composition		 Plxna3tm1Matl/Y
Plxna4tm1Matl/Plxna4tm1Matl
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna3tm1Matl mutation (1 available); any Plxna3 mutation (13 available)
Plxna4tm1Matl mutation (2 available); any Plxna4 mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:98440 )
• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated
abnormal sensory neuron innervation pattern ( J:98440 )
• starting at E11.5, had severely disrupted peripheral sensory projections, with many axons crossing the dorsal midline to the other side of the body at E12.5
• peripheral sensory projections exhibited extensive outgrowth and branching as if there were no boundaries for the axons
abnormal trigeminal nerve morphology ( J:98440 )
• severely disorganized and derasciculated ophthalmic, maxillary and mandibular projections at E11.5
• more fibers of the ophthalmic branch misprojected in different directions, and some even started to invade the eye region at E11.5 and the ophthalmic axon fibers covered the entire face, including the eyes and the fibers were thinner and heavily branched at E12.5 compared to wildtype
abnormal trochlear nerve morphology ( J:98440 )
• severely defasciculated even though individual axons could still be seen leaving the midbrain-hindbrain junction

cellular
abnormal axon guidance ( J:98440 )
• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated




Genotype
MGI:3590677
cx4
Allelic
Composition		 Plxna3tm1Matl/Plxna3tm1Matl
Plxna4tm1Matl/Plxna4tm1Matl
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna3tm1Matl mutation (1 available); any Plxna3 mutation (13 available)
Plxna4tm1Matl mutation (2 available); any Plxna4 mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:98440 )
• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated
abnormal sensory neuron innervation pattern ( J:98440 )
• starting at E11.5, had severely disrupted peripheral sensory projections, with many axons crossing the dorsal midline to the other side of the body at E12.5
• peripheral sensory projections exhibited extensive outgrowth and branching as if there were no boundaries for the axons
abnormal trigeminal nerve morphology ( J:98440 )
• severely disorganized and derasciculated ophthalmic, maxillary and mandibular projections at E11.5
• more fibers of the ophthalmic branch misprojected in different directions, and some even started to invade the eye region at E11.5 and the ophthalmic axon fibers covered the entire face, including the eyes and the fibers were thinner and heavily branched at E12.5 compared to wildtype
abnormal trochlear nerve morphology ( J:98440 )
• severely defasciculated even though individual axons could still be seen leaving the midbrain-hindbrain junction

cellular
abnormal axon guidance ( J:98440 )
• repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated




Genotype
MGI:5007634
cx5
Allelic
Composition		 Plxna4tm1Matl/Plxna4+
Sema6aGt(KST069)Byg/Sema6a+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna4tm1Matl mutation (2 available); any Plxna4 mutation (99 available)
Sema6aGt(KST069)Byg mutation (1 available); any Sema6a mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased sensory neuron number ( J:172268 )
• mice exhibit an increase in TH+ puncta in S4/S5 of the inner plexiform layer compared to in wild-type mice




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11/12/2024
MGI 6.24 		The Jackson Laboratory