Phenotypes associated with this allele

• Allele Symbol: H2^b
• Allele Name: b variant
• Allele ID: MGI:3579319
• Summary: 24 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2^b/H2^b	NOD.B10SnJ-H2^b	MGI:3628773
ht2	H2^b/H2^d	(C57BL/6 x DBA/2)F1	MGI:3630186
ht3	H2^b/H2^g7	NOD.B10SnJ-H2^b	MGI:3628790
cx4	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo	involves: 129P2/OlaHsd	MGI:3807285
cx5	H2^b/H2^b Tcra/Tcrd^tm1.1(Tcra)Rsky/Tcra/Tcrd^tm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807223
cx6	H2^b/H2^b Tcra^tm1Mom/Tcra/Tcrd^tm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807217
cx7	Tcra^tm1Mom/Tcra/Tcrd^tm1.1(Tcra)Rsky H2^b/H2^b Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807222
cx8	H2^b/H2^b Tcra/Tcrd^tm1.1(Tcra)Rsky/Tcra/Tcrd^tm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807224
cx9	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tcra^tm1Mom/Tcra/Tcrd^tm1.1(Tcra)Rsky Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807286
cx10	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807289
cx11	H2^b/H2^d Themis^tm1Gasc/Themis^tm1Gasc	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2	MGI:4353112
cx12	H2^b/H2^b Rag1^tm1Mom/Rag1^tm1Mom Tg(Tcra19,Tcrb19)#Stl/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:6305871
cx13	H2^b/H2^b Nfkbid^tm1Clay/Nfkbid^tm1Clay Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/?	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	MGI:3777767
cx14	H2^b/H2^b Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/?	involves: 129S/SvEv * C57BL/6	MGI:3777753
cx15	Apobec3^Gt(XN450)Byg/Apobec3^Rfv3-s H2^b/H2^b	involves: A.BY * C57BL/6	MGI:3809805
cx16	H2^b/H2^s Tg(TcraTcrb)1100Mjb/?	involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss	MGI:3783840
cx17	Apobec3^Gt(XN450)Byg/Apobec3^Rfv3-s H2^b/H2^d	involves: BALB/c * C57BL/6	MGI:3809804
cx18	H2^b/H2^d Tg(TcraTcrb)1100Mjb/?	involves: BALB/c * C57BL/6	MGI:3783839
cx19	H2^b/H2^d Tg(Ins2-E3)1Dvs/0	involves: BALB/c * C57BL/6 * DBA/2J	MGI:3785747
cx20	H2^b/H2^k Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/?	involves: C3H/HeJ * C57BL/6 * C57BL/10	MGI:4354598
cx21	H2^b/H2^b Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/?	involves: C3H/HeJ * C57BL/6 * C57BL/10	MGI:4354597
cx22	H2^b/H2^k Tg(TcraTcrb)1100Mjb/?	involves: C57BL/6 * C57BL/10Sg * C57BR/c	MGI:3783836
cx23	H2^b/H2^g7 Tg(TcraR28,TcrbR28)KRNDim/0	involves: C57BL/6 * NOD * SJL	MGI:3842820
cx24	Aire^tm1.1Doi/Aire^tm1.1Doi H2^b/H2^b	NOD.Cg-Aire^tm1.1Doi H2^b/Doi	MGI:3793704

Genotype
MGI:3628773

hm1

• Allelic Composition: H2^b/H2^b
• Genetic Background: NOD.B10SnJ-H2^b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:14178 )

• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

endocrine/exocrine glands

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

immune system

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation

Genotype
MGI:3630186

ht2

• Allelic Composition: H2^b/H2^d
• Genetic Background: (C57BL/6 x DBA/2)F1

immune system

abnormal T cell differentiation ( J:106141 )

• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

abnormal cytokine secretion ( J:106141 )

• levels of Ifng and Il4 are lower than in B6 mice with malarial infection

increased autoantibody level ( J:106141 )

• level of IgM autoantibody is increase to a greater extent than in B6 mice

decreased susceptibility to parasitic infection ( J:106141 )

• recovery from malaria is similar to DBA/2 mice, faster than in B6 mice

hematopoietic system

abnormal T cell differentiation ( J:106141 )

• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

decreased hematocrit ( J:106141 )

• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system

abnormal liver physiology ( J:106141 )

• liver injury as estimated by GPT serum levels is lower than in infected B6 mice

Genotype
MGI:3628790

ht3

• Allelic Composition: H2^b/H2^g7
• Genetic Background: NOD.B10SnJ-H2^b

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Genotype
MGI:3807285

cx4

• Allelic Composition: H2^b/H2^b; Ptcra^tm1Vbo/Ptcra^tm1Vbo
• Genetic Background: involves: 129P2/OlaHsd

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte number is decreased by 10-fold compared to controls

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is severely reduced in the thymocytes

spleen hypoplasia ( J:131357 )

• spleen numbers are reduced by more than 4-fold

immune system

decreased thymocyte number ( J:131357 )

• thymocyte number is decreased by 10-fold compared to controls

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is severely reduced in the thymocytes

spleen hypoplasia ( J:131357 )

• spleen numbers are reduced by more than 4-fold

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte number is decreased by 10-fold compared to controls

Genotype
MGI:3807223

cx5

• Allelic Composition: H2^b/H2^b; Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky}; Tg(Tcrb)93Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

immune system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

hematopoietic system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

Genotype
MGI:3807217

cx6

• Allelic Composition: H2^b/H2^b; Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky}; Tg(Tcrb)93Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

immune system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 thymocytes from H2-D^b background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 thymocytes from H2-D^b background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

Genotype
MGI:3807222

cx7

• Allelic Composition: Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky}; H2^b/H2^b; Tg(Tcrb)93Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

hematopoietic system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

immune system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

Genotype
MGI:3807224

cx8

• Allelic Composition: H2^b/H2^b; Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky}; Tg(Tcrb)93Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

hematopoietic system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

immune system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

Genotype
MGI:3807286

cx9

• Allelic Composition: H2^b/H2^b; Ptcra^tm1Vbo/Ptcra^tm1Vbo; Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky}; Tg(Tcrb)93Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Genotype
MGI:3807289

cx10

• Allelic Composition: H2^b/H2^b; Ptcra^tm1Vbo/Ptcra^tm1Vbo; Tg(TcraH-Y,TcrbH-Y)71Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

immune system

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcra^tm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen

• the presence of the selecting H2^d allele contributes to the rescue of T cell development by the HY-TCR

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcra^tm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen

• the presence of the selecting H2^d allele contributes to the rescue of T cell development by the HY-TCR

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

Genotype
MGI:4353112

cx11

• Allelic Composition: H2^b/H2^d; Themis^tm1Gasc/Themis^tm1Gasc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2

hematopoietic system

abnormal negative T cell selection ( J:151074 )

• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice

immune system

abnormal negative T cell selection ( J:151074 )

• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice

Genotype
MGI:6305871

cx12

• Allelic Composition: H2^b/H2^b; Rag1^tm1Mom/Rag1^tm1Mom; Tg(Tcra19,Tcrb19)#Stl/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

immune system

immune system phenotype ( J:19795 )

N • mice do not show signs of spontaneous autoimmune encephalomyelitis within 12 months and do not develop experimental autoimmune encephalomyelitis after immunization with myelin basic protein (MBP)

Genotype
MGI:3777767

cx13

• Allelic Composition: H2^b/H2^b; Nfkbid^tm1Clay/Nfkbid^tm1Clay; Rag2^tm1Fwa/Rag2^tm1Fwa; Tg(TcraN15,TcrbN15)L2Elre/?
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

immune system

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

decreased interleukin-2 secretion ( J:132071 )

• lymph node T cells secrete significantly less IL-2 than wild-type T cells in response to irradiated spleen cells loaded with VSV8 antigen

hematopoietic system

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

endocrine/exocrine glands

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

cellular

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

Genotype
MGI:3777753

cx14

• Allelic Composition: H2^b/H2^b; Rag2^tm1Fwa/Rag2^tm1Fwa; Tg(TcraN15,TcrbN15)L2Elre/?
• Genetic Background: involves: 129S/SvEv * C57BL/6

immune system

increased T cell proliferation ( J:133112 )

• CD8 T cells proliferate when presented VSV8 peptide by antigen presenting cells

arrested T cell differentiation ( J:133112 )

• the majority of T cells in the thymus are arrested at the double positive stage

• single positive CD4 positive T cells are absent in the thymus

• there is a reduced percentage of single positive CD8 positive T cells

• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background

• injection of the VSV8 antigen leads to rapid apoptosis and depletion of double-positive thymocytes with a 3-6 fold drop in total number of thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:133112 )

• there are almost 10-fold less CD4 T cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:133112 )

• there are about 4-fold more CD8 T cells in the spleen

abnormal cytotoxic T cell physiology ( J:133112 )

• CD8 positive T cells exhibit increased cytotoxicity towards cells loaded with VSV8 peptide

hematopoietic system

increased T cell proliferation ( J:133112 )

• CD8 T cells proliferate when presented VSV8 peptide by antigen presenting cells

arrested T cell differentiation ( J:133112 )

• the majority of T cells in the thymus are arrested at the double positive stage

• single positive CD4 positive T cells are absent in the thymus

• there is a reduced percentage of single positive CD8 positive T cells

• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background

• injection of the VSV8 antigen leads to rapid apoptosis and depletion of double-positive thymocytes with a 3-6 fold drop in total number of thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:133112 )

• there are almost 10-fold less CD4 T cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:133112 )

• there are about 4-fold more CD8 T cells in the spleen

abnormal cytotoxic T cell physiology ( J:133112 )

• CD8 positive T cells exhibit increased cytotoxicity towards cells loaded with VSV8 peptide

cellular

increased T cell proliferation ( J:133112 )

• CD8 T cells proliferate when presented VSV8 peptide by antigen presenting cells

Genotype
MGI:3809805

cx15

• Allelic Composition: Apobec3^Gt(XN450)Byg/Apobec3^Rfv3-s; H2^b/H2^b
• Genetic Background: involves: A.BY * C57BL/6

immune system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls

hematopoietic system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls

Genotype
MGI:3783840

cx16

• Allelic Composition: H2^b/H2^s; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss

immune system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands

small thymus ( J:133645 )

• the thymus is smaller than normal

Genotype
MGI:3809804

cx17

• Allelic Composition: Apobec3^Gt(XN450)Byg/Apobec3^Rfv3-s; H2^b/H2^d
• Genetic Background: involves: BALB/c * C57BL/6

mortality/aging

increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls

increased susceptibility to Retroviridae infection ( J:138778 )

• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls

Genotype
MGI:3783839

cx18

• Allelic Composition: H2^b/H2^d; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: BALB/c * C57BL/6

immune system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands

small thymus ( J:133645 )

• the thymus is smaller than normal

Genotype
MGI:3785747

cx19

• Allelic Composition: H2^b/H2^d; Tg(Ins2-E3)1Dvs/0
• Genetic Background: involves: BALB/c * C57BL/6 * DBA/2J

immune system

increased length of allograft survival ( J:109763 )

• when transferred into BALB/c hosts, but not C57BL/6 hosts, pancreatic islets from H2 survive much longer than non-transgenic pancreatic islets

Genotype
MGI:4354598

cx20

• Allelic Composition: H2^b/H2^k; Itk^tm1Ljb/Itk^tm1Ljb; Tg(TcrAND)53Hed/?
• Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

immune system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

hematopoietic system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

Genotype
MGI:4354597

cx21

• Allelic Composition: H2^b/H2^b; Itk^tm1Ljb/Itk^tm1Ljb; Tg(TcrAND)53Hed/?
• Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

immune system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• there are almost no mature transgenic CD4 T cells in the periphery

hematopoietic system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• there are almost no mature transgenic CD4 T cells in the periphery

Genotype
MGI:3783836

cx22

• Allelic Composition: H2^b/H2^k; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: C57BL/6 * C57BL/10Sg * C57BR/c

immune system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands

small thymus ( J:133645 )

• the thymus is smaller than normal

Genotype
MGI:3842820

cx23

• Allelic Composition: H2^b/H2^g7; Tg(TcraR28,TcrbR28)KRNDim/0
• Genetic Background: involves: C57BL/6 * NOD * SJL

immune system

mitral valve inflammation ( J:275827 )

• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease

• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes

• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves

• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening

rheumatoid arthritis ( J:36815 , J:275827 )

• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)

• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

cardiovascular system

abnormal mitral valve morphology ( J:275827 )

• mitral valve hydroxyproline content is elevated

thick mitral valve ( J:275827 )

• by 8 weeks of age, mitral valves are fibrotic and thickened

• TNFR2 neutralization with a monoclonal antibody exacerbates mitral valve fibrosis and thickening

• blockade of either VLA-4 or VCAM-1 with monoclonal antibodies attenuates valve fibrosis and thickening

mitral valve inflammation ( J:275827 )

• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease

• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes

• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves

• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening

homeostasis/metabolism

increased hydroxyproline level ( J:275827 )

• mitral valve hydroxyproline content is elevated

skeleton

rheumatoid arthritis ( J:36815 , J:275827 )

• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)

• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mitral valve disease		DOID:61		J:275827
rheumatoid arthritis		DOID:7148	OMIM:180300	J:36815

Genotype
MGI:3793704

cx24

• Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi; H2^b/H2^b
• Genetic Background: NOD.Cg-Aire^tm1.1Doi H2^b/Doi

immune system

stomach inflammation ( J:107432 )

• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

digestive/alimentary system

stomach inflammation ( J:107432 )

• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

endocrine/exocrine glands

abnormal pancreas physiology ( J:107432 )

• Background Sensitivity: the pancreatitis associated with the Aire^tm1.1Doi allele on the NOD background is absent when the H2^g7 allele is present at homozygocity