All Phenotypes H2<d> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2^d/H2^d	DBA/2	MGI:3630183
ht2	H2^b/H2^d	(C57BL/6 x DBA/2)F1	MGI:3630186
cx3	H2^d/H2^d Trap1a^tm1.1Jvde/Trap1a^tm1.1Jvde	involves: 129 * BALB/cJ * C57BL/10 * DBA/2	MGI:5310746
cx4	H2^d/H2^d Trap1a^tm1.1Jvde/Y	involves: 129 * BALB/cJ * C57BL/10 * DBA/2	MGI:5310747
cx5	H2^d/H2^d Tg(TcraP1.5,TcrbP1.5)29Amsv/0 Trap1a^tm1.1Jvde/Y	involves: 129 * BALB/cJ * C57BL/10 * DBA/2	MGI:5310748
cx6	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807288
cx7	H2^d/H2^d Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807291
cx8	H2^d/H2^d Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/?	involves: 129S/SvEv * C57BL/6	MGI:3777752
cx9	H2^b/H2^d Themis^tm1Gasc/Themis^tm1Gasc	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2	MGI:4353112
cx10	H2^b/H2^d Tg(TcraTcrb)1100Mjb/?	involves: BALB/c * C57BL/6	MGI:3783839
cx11	Apobec3^Gt(XN450)Byg/Apobec3^Rfv3-s H2^b/H2^d	involves: BALB/c * C57BL/6	MGI:3809804
cx12	H2^b/H2^d Tg(Ins2-E3)1Dvs/0	involves: BALB/c * C57BL/6 * DBA/2J	MGI:3785747
cx13	Dh/Dh⁺ H2^d/H2^d	NZB.Cg-Dh	MGI:3819783

Allelic Composition	H2^d/H2^d
Genetic Background	DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:106141 )

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

• in livers of mice, population of extrathymic T cells begins to expand from the acute phase to the recovery phase, more prominently than in B6 mice

• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection

abnormal cytokine secretion ( J:106141 )

• levels of Ifng and Il4 are lower than in B6 mice with malarial infection

increased autoantibody level ( J:106141 )

• level of IgM autoantibody is increase to a greater extent than in B6 mice

decreased susceptibility to parasitic infection ( J:106141 )

• when infected with P. yoelii, DBA/2 mice recover more quickly from malaria than C57BL/6 mice; duration of parasitemia is short and of a low degree

hematopoietic system

abnormal T cell differentiation ( J:106141 )

• in livers of mice, population of extrathymic T cells begins to expand from the acute phase to the recovery phase, more prominently than in B6 mice

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

decreased hematocrit ( J:106141 )

• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system

abnormal liver physiology ( J:106141 )

• liver injury as estimated by GPT serum levels is lower than in infected B6 mice

Allelic Composition	H2^b/H2^d
Genetic Background	(C57BL/6 x DBA/2)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
H2^d mutation (23 available); any H2 mutation (282 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:106141 )

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

abnormal cytokine secretion ( J:106141 )

• levels of Ifng and Il4 are lower than in B6 mice with malarial infection

increased autoantibody level ( J:106141 )

• level of IgM autoantibody is increase to a greater extent than in B6 mice

decreased susceptibility to parasitic infection ( J:106141 )

• recovery from malaria is similar to DBA/2 mice, faster than in B6 mice

hematopoietic system

abnormal T cell differentiation ( J:106141 )

• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-

decreased hematocrit ( J:106141 )

• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system

abnormal liver physiology ( J:106141 )

• liver injury as estimated by GPT serum levels is lower than in infected B6 mice

Allelic Composition	H2^d/H2^d Trap1a^tm1.1Jvde/Trap1a^tm1.1Jvde
Genetic Background	involves: 129 * BALB/cJ * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Trap1a^tm1.1Jvde mutation (0 available); any Trap1a mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:180807 )

N	• mice are fertile

Allelic Composition	H2^d/H2^d Trap1a^tm1.1Jvde/Y
Genetic Background	involves: 129 * BALB/cJ * C57BL/10 * DBA/2

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:180807 )

• mice exhibit spontaneous rejection of P815 tumors and increased survival compared with wild-type mice

reproductive system

reproductive system phenotype ( J:180807 )

N	• mice are fertile

immune system

abnormal CD8-positive, alpha-beta T cell physiology ( J:180807 )

• P1A35-43-specific CD8 T lymphocytes exhibit increased functional avidity compared with wild-type cells

abnormal immune tolerance ( J:180807 )

• mice exhibit increased immunogenic response towards P1A35-43 compared with wild-type mice

neoplasm

tumor regression ( J:180807 )

• mice exhibit spontaneous rejection of P815 tumors and increased survival compared with wild-type mice

hematopoietic system

abnormal CD8-positive, alpha-beta T cell physiology ( J:180807 )

• P1A35-43-specific CD8 T lymphocytes exhibit increased functional avidity compared with wild-type cells

Allelic Composition	H2^d/H2^d Tg(TcraP1.5,TcrbP1.5)29Amsv/0 Trap1a^tm1.1Jvde/Y
Genetic Background	involves: 129 * BALB/cJ * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Tg(TcraP1.5,TcrbP1.5)29Amsv mutation (0 available)
Trap1a^tm1.1Jvde mutation (0 available); any Trap1a mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell clonal deletion ( J:180807 )

• T lymphocytes expressing the transgene are negatively selected in the thymus and strongly reduced in the periphery

hematopoietic system

abnormal T cell clonal deletion ( J:180807 )

• T lymphocytes expressing the transgene are negatively selected in the thymus and strongly reduced in the periphery

Allelic Composition	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (16 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	H2^d/H2^d Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	H2^d/H2^d Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(TcraN15,TcrbN15)L2Elre mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested T cell differentiation ( J:133112 )

• the majority of T cells in the thymus are arrested at the double positive stage

• single positive T cells are virtually absent

• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background

decreased CD4-positive, alpha-beta T cell number ( J:133112 )

• mature CD4 T cells are severely reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:133112 )

• mature CD8 T cells are virtually absent in the spleen

hematopoietic system

arrested T cell differentiation ( J:133112 )

• the majority of T cells in the thymus are arrested at the double positive stage

• single positive T cells are virtually absent

• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background

decreased CD4-positive, alpha-beta T cell number ( J:133112 )

• mature CD4 T cells are severely reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:133112 )

• mature CD8 T cells are virtually absent in the spleen

Allelic Composition	H2^b/H2^d Themis^tm1Gasc/Themis^tm1Gasc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
H2^d mutation (23 available); any H2 mutation (282 available)
Themis^tm1Gasc mutation (1 available); any Themis mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal negative T cell selection ( J:151074 )

• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice

immune system

abnormal negative T cell selection ( J:151074 )

• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice

Allelic Composition	H2^b/H2^d Tg(TcraTcrb)1100Mjb/?
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands

small thymus ( J:133645 )

• the thymus is smaller than normal

Allelic Composition	Apobec3^Gt(XN450)Byg/Apobec3^Rfv3-s H2^b/H2^d
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3^Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (127 available)
Apobec3^Rfv3-s mutation (1 available); any Apobec3 mutation (127 available)
H2^b mutation (30 available); any H2 mutation (282 available)
H2^d mutation (23 available); any H2 mutation (282 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls

increased susceptibility to Retroviridae infection ( J:138778 )

• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls

Allelic Composition	H2^b/H2^d Tg(Ins2-E3)1Dvs/0
Genetic Background	involves: BALB/c * C57BL/6 * DBA/2J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased length of allograft survival ( J:109763 )

• when transferred into BALB/c hosts, but not C57BL/6 hosts, pancreatic islets from H2 survive much longer than non-transgenic pancreatic islets

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

cryptorchism ( J:12036 )

• approximately 10-15% of males suffer from this

reduced fertility ( J:12036 )

• cryptorchism in some males, infertility in some females, and mounting difficulties due to limb abnormalities all lead to reduced fecundity

reduced female fertility ( J:12036 )

• 25% of females are sterile

limbs/digits/tail

polyphalangy ( J:12036 )

• preaxial triphalangy and /or poly-, syn- or oligodactyly of the hindfeet are characteristic of mice carrying the Dh allele

immune system

decreased B cell proliferation ( J:12036 )

• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls

• no differences are found in B cells from mice 7 months of age

increased T cell proliferation ( J:12036 )

• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls

• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts

absent spleen ( J:12036 )

• an absent spleen is characteristic of mice carrying the Dh allele

decreased IgG level ( J:12036 )

• at six months of age, the mean IgG2 level is 2.32 mg/ml compared to 4.37 mg/ml in NZB controls

• at one year of age, the mean IgG2 level is 3.70 mg/ml compared to 6.38 mg/ml in NZB controls

decreased IgG1 level ( J:12036 )

• at six months of age, the mean IgG1 level is 1.39 mg/ml compared to 1.84 mg/ml in NZB controls

• at one year of age, the mean IgG1 level is 1.45 mg/ml compared to 2.17 mg/ml in NZB controls

decreased IgM level ( J:12036 )

• at three months of age, the mean IgM level is 0.13 mg/ml compared to 0.45 mg/ml in NZB controls

• at six months of age, the mean IgM level is 0.35 mg/ml compared to 0.79 mg/ml in NZB controls

• at one year of age, the mean IgM level is 0.57 mg/ml compared to 1.38 mg/ml in NZB controls

increased autoantibody level ( J:12036 )

• Background Sensitivity: mice have increased levels of "naturally occurring thymocytotoxic IgM antibodies" (NTA) compared to NZB controls

• Background Sensitivity: 8 of 9 mice at 6 weeks of age have significant levels of NTAs compared to none in a similar sized group of age-matched NZB mice

• Background Sensitivity: at one year of age, all mice have a mean NTA log₂titer of 4.5 compared to 60% of NZB controls with detectable amounts of NTA with a mean titer of 2.2

increased anti-erythrocyte antigen antibody level ( J:12036 )

• Background Sensitivity: 100% of animals by 9 months of age have detectable levels of anti-erythrocyte antibodies (i.e. positive Coombs' test)

• Background Sensitivity: while anti-erythrocyte antibodies are characteristic of the NZB strain, there are differences with this mouse strain in the immunoglobulin classes involved

• Background Sensitivity: one year old mice have a four-fold decrease in the serum level of anti-erythrocyte IgM with a corresponding increase in anti-erythrocyte IgG1

• Background Sensitivity: sheep red blood cells injected into 3 but not 9 month old mice have higher levels of agglutinating antibody coating the cells than in NZB controls t

increased anti-nuclear antigen antibody level ( J:12036 )

• Background Sensitivity: 30% of mice at 3 months of age and 90% of mice at 9 months of age have detectable levels of anti-polyIpolyC antibodies, which is similar to NZB controls

increased anti-single stranded DNA antibody level ( J:12036 )

• Background Sensitivity: 30% of mice at 3 months of age and 90% of mice at 9 months of age have detectable levels of anti-single stranded DNA antibodies, which is similar to NZB controls

glomerulonephritis ( J:12036 )

• Background Sensitivity: mice develop a glomular disease similar to NZB controls except that there is no evidence of lymphocytic infiltrate, which occurs in 80% of the NZB controls

decreased susceptibility to graft versus host disease ( J:12036 )

• thymocytes isolated from these mice at 20 weeks of age are better able to suppress graft versus host disease (GVHD )than controls in an induced form of GVHD caused by transfer with wild-type NZB splenocytes into an irradiated host

• similar suppression of GVHD as controls is observed when thymocytes are isolated from 4 week old mice

renal/urinary system

glomerulonephritis ( J:12036 )

• Background Sensitivity: mice develop a glomular disease similar to NZB controls except that there is no evidence of lymphocytic infiltrate, which occurs in 80% of the NZB controls

neoplasm

decreased lymphoma incidence ( J:12036 )

• Background Sensitivity: lymphomas, which occur in 11% of NZB mice by one year of age, are not observed in these mice

endocrine/exocrine glands

cryptorchism ( J:12036 )

• approximately 10-15% of males suffer from this

skeleton

polyphalangy ( J:12036 )

• preaxial triphalangy and /or poly-, syn- or oligodactyly of the hindfeet are characteristic of mice carrying the Dh allele

hematopoietic system

decreased B cell proliferation ( J:12036 )

• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls

• no differences are found in B cells from mice 7 months of age

increased T cell proliferation ( J:12036 )

• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls

• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts

absent spleen ( J:12036 )

• an absent spleen is characteristic of mice carrying the Dh allele

decreased IgG level ( J:12036 )

• at six months of age, the mean IgG2 level is 2.32 mg/ml compared to 4.37 mg/ml in NZB controls

• at one year of age, the mean IgG2 level is 3.70 mg/ml compared to 6.38 mg/ml in NZB controls

decreased IgG1 level ( J:12036 )

• at six months of age, the mean IgG1 level is 1.39 mg/ml compared to 1.84 mg/ml in NZB controls

• at one year of age, the mean IgG1 level is 1.45 mg/ml compared to 2.17 mg/ml in NZB controls

decreased IgM level ( J:12036 )

• at three months of age, the mean IgM level is 0.13 mg/ml compared to 0.45 mg/ml in NZB controls

• at six months of age, the mean IgM level is 0.35 mg/ml compared to 0.79 mg/ml in NZB controls

• at one year of age, the mean IgM level is 0.57 mg/ml compared to 1.38 mg/ml in NZB controls

cellular

decreased B cell proliferation ( J:12036 )

• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls

• no differences are found in B cells from mice 7 months of age

increased T cell proliferation ( J:12036 )

• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls

• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts

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