Phenotypes associated with this allele

• Allele Symbol: H2^g7
• Allele Name: g7 variant
• Allele ID: MGI:3579321
• Summary: 15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	H2^b/H2^g7	NOD.B10SnJ-H2^b	MGI:3628790
ht2	H2^h2/H2^g7	NOD.Cg-H2^h2	MGI:3628788
ht3	H2^h4/H2^g7	NOD.Cg-H2^h4	MGI:3628787
ht4	H2^i5/H2^g7	NOD.Cg-H2^i5	MGI:3628789
ht5	H2^i7/H2^g7	NOD.Cg-H2^i7	MGI:3628791
ht6	H2^k/H2^g7	NOD.Cg-H2^k	MGI:3628792
ht7	H2^i7/H2^g7	(NOD x NOD.Cg-H2^i7)F1	MGI:3628793
cx8	H2^g7/H2^g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0	B6.Cg-H2^g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi	MGI:3640480
cx9	H2^g7/H2^g7 Tg(TcraAI4)1Dvs/0 Tg(TcrbAI4)1Dvs/0	B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs	MGI:4868729
cx10	H2^g7/H2^g7 Ins2^tm1Jja/Ins2^tm1Jja Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD	MGI:3687167
cx11	H2^g7/H2^g7 Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	MGI:3687164
cx12	H2^g7/H2^g7 Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	MGI:3687169
cx13	H2^g7/H2^q Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	MGI:3687165
cx14	H2^b/H2^g7 Tg(TcraR28,TcrbR28)KRNDim/0	involves: C57BL/6 * NOD * SJL	MGI:3842820
cx15	H2^g7/H2^g7 Tg(Ins2-Vtcn1)#Xxz/0 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0	involves: C57BL/6 * NOD * SJL	MGI:5463746

Genotype
MGI:3628790

ht1

• Allelic Composition: H2^b/H2^g7
• Genetic Background: NOD.B10SnJ-H2^b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Genotype
MGI:3628788

ht2

• Allelic Composition: H2^h2/H2^g7
• Genetic Background: NOD.Cg-H2^h2

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Genotype
MGI:3628787

ht3

• Allelic Composition: H2^h4/H2^g7
• Genetic Background: NOD.Cg-H2^h4

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Genotype
MGI:3628789

ht4

• Allelic Composition: H2ⁱ⁵/H2^g7
• Genetic Background: NOD.Cg-H2ⁱ⁵

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Genotype
MGI:3628791

ht5

• Allelic Composition: H2ⁱ⁷/H2^g7
• Genetic Background: NOD.Cg-H2ⁱ⁷

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Genotype
MGI:3628792

ht6

• Allelic Composition: H2^k/H2^g7
• Genetic Background: NOD.Cg-H2^k

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Genotype
MGI:3628793

ht7

• Allelic Composition: H2ⁱ⁷/H2^g7
• Genetic Background: (NOD x NOD.Cg-H2ⁱ⁷)F1

endocrine/exocrine glands

insulitis ( J:14178 )

♂ • no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis

immune system

insulitis ( J:14178 )

♂ • no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis

Genotype
MGI:3640480

cx8

• Allelic Composition: H2^g7/H2^g7; Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: B6.Cg-H2^g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

immune system

decreased susceptibility to autoimmune diabetes ( J:86926 )

• animals show a significant reduction in overall diabetes incidence (14.6% vs ~50% in Tnfsf4-heterozygotes and wild-type) and increase in the age of onset (9.5 weeks vs 6 weeks in controls)

• mice are considered diabetic after a blood glucose measure of >300 mg/dl and 2 positive urine glucose tests

Genotype
MGI:4868729

cx9

• Allelic Composition: H2^g7/H2^g7; Tg(TcraAI4)1Dvs/0; Tg(TcrbAI4)1Dvs/0
• Genetic Background: B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs

immune system

increased susceptibility to autoimmune diabetes ( J:167508 )

• Background Sensitivity: although negative selection of these transgenic thymocytes is stronger on the B6 than NOD background, there is earlier onset and greater penetrance of diabetes in females on the B6 background

• Background Sensitivity: compared with those on the NOD background, on the B6 background these TCR transgenic T cells have greater proliferative response to antigen presentation and display more potent killing of pancreatic islet cells

Genotype
MGI:3687167

cx10

• Allelic Composition: H2^g7/H2^g7; Ins2^tm1Jja/Ins2^tm1Jja; Rag1^tm1Mom/Rag1^tm1Mom; Tg(TcraBDC12-4.1)10Jos/0; Tg(TcrbBDC12-4.1)82Gse/0
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD

homeostasis/metabolism

increased circulating glucose level ( J:111874 )

immune system

increased susceptibility to autoimmune diabetes ( J:111874 )

• mice develop diabetes (blood glucose >250 ml/dl) more rapidly than transgenic Rag1-null, Ins2-sufficient mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:111874

Genotype
MGI:3687164

cx11

• Allelic Composition: H2^g7/H2^g7; Rag1^tm1Mom/Rag1^tm1Mom; Tg(TcraBDC12-4.1)10Jos/0; Tg(TcrbBDC12-4.1)82Gse/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

endocrine/exocrine glands

insulitis ( J:111874 )

• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

immune system

insulitis ( J:111874 )

• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

increased susceptibility to autoimmune diabetes ( J:111874 )

• 15% of mice heterozygous for H2^g7 develop diabetes, compared to 50% of homozygous mice or 0% of non-H2^g7 mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:111874

Genotype
MGI:3687169

cx12

• Allelic Composition: H2^g7/H2^g7; Tg(TcraBDC12-4.1)10Jos/0; Tg(TcrbBDC12-4.1)82Gse/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

endocrine/exocrine glands

insulitis ( J:111874 )

• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected

immune system

insulitis ( J:111874 )

• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected

decreased susceptibility to autoimmune diabetes ( J:111874 )

• transgenic Rag1-sufficient mice do not develop diabetes

Genotype
MGI:3687165

cx13

• Allelic Composition: H2^g7/H2^q; Rag1^tm1Mom/Rag1^tm1Mom; Tg(TcraBDC12-4.1)10Jos/0; Tg(TcrbBDC12-4.1)82Gse/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

immune system

increased susceptibility to autoimmune diabetes ( J:111874 )

• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:111874

Genotype
MGI:3842820

cx14

• Allelic Composition: H2^b/H2^g7; Tg(TcraR28,TcrbR28)KRNDim/0
• Genetic Background: involves: C57BL/6 * NOD * SJL

immune system

mitral valve inflammation ( J:275827 )

• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease

• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes

• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves

• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening

rheumatoid arthritis ( J:36815 , J:275827 )

• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)

• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

cardiovascular system

abnormal mitral valve morphology ( J:275827 )

• mitral valve hydroxyproline content is elevated

thick mitral valve ( J:275827 )

• by 8 weeks of age, mitral valves are fibrotic and thickened

• TNFR2 neutralization with a monoclonal antibody exacerbates mitral valve fibrosis and thickening

• blockade of either VLA-4 or VCAM-1 with monoclonal antibodies attenuates valve fibrosis and thickening

mitral valve inflammation ( J:275827 )

• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease

• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes

• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves

• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening

homeostasis/metabolism

increased hydroxyproline level ( J:275827 )

• mitral valve hydroxyproline content is elevated

skeleton

rheumatoid arthritis ( J:36815 , J:275827 )

• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)

• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mitral valve disease		DOID:61		J:275827
rheumatoid arthritis		DOID:7148	OMIM:180300	J:36815

Genotype
MGI:5463746

cx15

• Allelic Composition: H2^g7/H2^g7; Tg(Ins2-Vtcn1)#Xxz/0; Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: involves: C57BL/6 * NOD * SJL

immune system

decreased regulatory T cell number ( J:177612 )

• in the pancreas

decreased interferon-gamma secretion ( J:177612 )

• from CD4+ pancreatic T cells

decreased interleukin-17 secretion ( J:177612 )

• from CD4+ pancreatic T cells

decreased susceptibility to autoimmune diabetes ( J:177612 )

• diabetes disease progression is abrogated compared to in control mice

• however, mice develop insulitis

hematopoietic system

decreased regulatory T cell number ( J:177612 )

• in the pancreas