Phenotypes associated with this allele

• Allele Symbol: H2^q
• Allele Name: q variant
• Allele ID: MGI:3579324
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^q/? Ncf1^m1J/Ncf1^m1J	B6.Cg-Ncf1^m1J H2^q	MGI:3709555
cx2	H2^g7/H2^q Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	MGI:3687165
cx3	H2^q/H2^q Rag1^tm1Mom/Rag1^tm1Mom Tg(TcraBDC12-4.1)10Jos/0 Tg(TcrbBDC12-4.1)82Gse/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD	MGI:3687166

Genotype
MGI:3709555

cx1

• Allelic Composition: H2^q/?; Ncf1^m1J/Ncf1^m1J
• Genetic Background: B6.Cg-Ncf1^m1J H2^q

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ncf1^m1J/ Ncf1^m1J mice carrying the H2^q haplotype develop enhanced collagen II autoimmunity and chronic collagen II induced arthritis

immune system

increased susceptibility to type IV hypersensitivity reaction ( J:92437 )

• the delayed-type hypersensitivity response against collagen II, not but OVA, is elevated compared to wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:92437 )

• MOG(79-96) peptide-induced EAE is milder in mutants than in wild-type

increased susceptibility to experimental autoimmune encephalomyelitis ( J:92437 )

• MOG protein-induced EAE is more severe in mutants than in wild-type

increased susceptibility to induced arthritis ( J:92437 )

• mutants exhibit increased susceptibility to collagen II induced arthritis, developing more severe arthritis and earlier onset than wild-type

• levels of antibodies directed against the injected collagen II antigen are higher, with a predominant increase in IgG

rheumatoid arthritis ( J:92437 )

• many females develop severe arthritis during the first days after partus; arthritis is as severe and chronic as the collagen II induced arthritis

• females exhibit massive destruction of bone and cartilage in the ankle joint and have an elevated amount of antibodies against collagen II

skeleton

increased susceptibility to induced arthritis ( J:92437 )

• mutants exhibit increased susceptibility to collagen II induced arthritis, developing more severe arthritis and earlier onset than wild-type

• levels of antibodies directed against the injected collagen II antigen are higher, with a predominant increase in IgG

rheumatoid arthritis ( J:92437 )

• many females develop severe arthritis during the first days after partus; arthritis is as severe and chronic as the collagen II induced arthritis

• females exhibit massive destruction of bone and cartilage in the ankle joint and have an elevated amount of antibodies against collagen II

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
rheumatoid arthritis		DOID:7148	OMIM:180300	J:92437

Genotype
MGI:3687165

cx2

• Allelic Composition: H2^g7/H2^q; Rag1^tm1Mom/Rag1^tm1Mom; Tg(TcraBDC12-4.1)10Jos/0; Tg(TcrbBDC12-4.1)82Gse/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

immune system

increased susceptibility to autoimmune diabetes ( J:111874 )

• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:111874

Genotype
MGI:3687166

cx3

• Allelic Composition: H2^q/H2^q; Rag1^tm1Mom/Rag1^tm1Mom; Tg(TcraBDC12-4.1)10Jos/0; Tg(TcrbBDC12-4.1)82Gse/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD

immune system

decreased susceptibility to autoimmune diabetes ( J:111874 )

• O% of mice homozygous for H2^q develop diabetes

digestive/alimentary system

digestive/alimentary phenotype ( J:111874 )

N • mice do not develop insulitis