Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Angptl6)8.1Yo
• Allele Name: transgene insertion 8.1, Yuichi Oike
• Allele ID: MGI:3579408
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Angptl6)8.1Yo/0	involves: C57BL/6 * CBA	MGI:3579418

Genotype
MGI:3579418

tg1

• Allelic Composition: Tg(CAG-Angptl6)8.1Yo/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:97552 )

• 5-month old transgenic mice show marked reductions in body weight

weight loss ( J:97552 )

• no difference in body weight at birth, however a reduction in body weight was noted at 4 weeks of age and persisted throughout life

decreased susceptibility to diet-induced obesity ( J:97552 )

• 8-week-old homozygous females were resistant to diet-induced obesity and exhibited few changes in visceral and subcutaneous fat depots and had markedly smaller white adipose tissue than wildtype

• plasma insulin levels were much lower compared to wildtype when fed a high-fat diet

adipose tissue

decreased total body fat amount ( J:97552 )

abnormal white adipose tissue morphology ( J:97552 )

• adipocytes are smaller in size

decreased white adipose tissue amount ( J:97552 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:97552 )

• 8-week-old homozygous females were resistant to diet-induced obesity and exhibited few changes in visceral and subcutaneous fat depots and had markedly smaller white adipose tissue than wildtype

• plasma insulin levels were much lower compared to wildtype when fed a high-fat diet

abnormal circulating hormone level ( J:97552 )

• serum adiponectin levels per white adipose tissue mass were markedly increased compared to wildtype

decreased circulating leptin level ( J:97552 )

increased oxygen consumption ( J:97552 )

• increase in whole-body oxygen consumption rates

increased insulin sensitivity ( J:97552 )

• increased insulin sensitivity despite the greatly decreased serum leptin levels

increased adiponectin level ( J:97552 )

• serum adiponectin levels per white adipose tissue mass were markedly increased compared to wildtype

cardiovascular system

abnormal blood vessel morphology ( J:97552 )

• increase in the number of capillary-sized vessels in skeletal muscles