Analysis Tools|
Allele Symbol Allele Name Allele ID |
Emx2tm2(cre)Sia targeted mutation 2, Shinichi Aizawa MGI:3579416 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all utricular hair cells are oriented in a single direction
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• all utricular hair cells are oriented in a single direction
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• born alive but do not survive beyond P10
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• increase in apoptosis at E13.5, primarily located in layers V-VI of the cortex
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• in culture ventricular zone cells are less likely to develop into neurospheres of greater than 50 um in diameter indicating impaired proliferation
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• decrease in the number of early born layer V and VI neurons at E12.5
• decrease in the number of Ctip2+ layer V and VI neurons, Tbr1+ layer VI neurons and Tbr2+ basal progenitors in the cortex at E14.5 and E16.5
• increase in the number of Cux1+ and Satb2+ upper layer neurons at E18.5
• smaller cortex at E18.5 and P7
• severe reduction in the number of Ctip2+ layer V and VI neurons at P7
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• increase in apoptosis at E13.5, primarily located in layers V-VI
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• increase in the number of astrocytes in the cortex at E18.5 and P7
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• in culture neural progenitor cells from E14.5 embryos more readily differentiate into astrocytes
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• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex
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• impairment of early neurogenesis indicated by decrease in the populations of deep layer neurons at E18.5
• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex
• partial reduction in the migration of GABAergic neurons into the dorsal telencephalon at E18.5
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• increase in the number of Brn2+ layer II-III neurons in the cortical plate at E14.5 and E16.5
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• decrease in the number of basal progenitors (Tbr2+) at E11.5 and E12.5
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• decrease in the number of early born layer V and VI neurons at E12.5
• decrease in the number of Ctip2+ layer V and VI neurons, Tbr1+ layer VI neurons and Tbr2+ basal progenitors in the cortex at E14.5 and E16.5
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• increase in the number of Cux1+ and Satb2+ upper layer neurons at E18.5
• increase in the number of Brn2+ layer II-III neurons in the cortical plate at E14.5 and E16.5
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• increase in apoptosis at E13.5, primarily located in layers V-VI of the cortex
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• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex
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• in culture ventricular zone cells are less likely to develop into neurospheres of greater than 50 um in diameter indicating impaired proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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