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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Emx2tm2(cre)Sia
targeted mutation 2, Shinichi Aizawa
MGI:3579416
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Emx2tm2(cre)Sia/Emx2tm2(cre)Sia involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:7520620
cn2
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
Emx2tm2(cre)Sia/Emx2+
involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5440721


Genotype
MGI:7520620
hm1
Allelic
Composition
Emx2tm2(cre)Sia/Emx2tm2(cre)Sia
Genetic
Background
involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2tm2(cre)Sia mutation (1 available); any Emx2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• all utricular hair cells are oriented in a single direction

nervous system
• all utricular hair cells are oriented in a single direction




Genotype
MGI:5440721
cn2
Allelic
Composition
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
Emx2tm2(cre)Sia/Emx2+
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2tm2(cre)Sia mutation (1 available); any Emx2 mutation (24 available)
Setdb1tm1.1Yshk mutation (1 available); any Setdb1 mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born alive but do not survive beyond P10

nervous system
• increase in apoptosis at E13.5, primarily located in layers V-VI of the cortex
• in culture ventricular zone cells are less likely to develop into neurospheres of greater than 50 um in diameter indicating impaired proliferation
• decrease in the number of early born layer V and VI neurons at E12.5
• decrease in the number of Ctip2+ layer V and VI neurons, Tbr1+ layer VI neurons and Tbr2+ basal progenitors in the cortex at E14.5 and E16.5
• increase in the number of Cux1+ and Satb2+ upper layer neurons at E18.5
• smaller cortex at E18.5 and P7
• severe reduction in the number of Ctip2+ layer V and VI neurons at P7
• increase in apoptosis at E13.5, primarily located in layers V-VI
• increase in the number of astrocytes in the cortex at E18.5 and P7
• in culture neural progenitor cells from E14.5 embryos more readily differentiate into astrocytes
• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex
• impairment of early neurogenesis indicated by decrease in the populations of deep layer neurons at E18.5
• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex
• partial reduction in the migration of GABAergic neurons into the dorsal telencephalon at E18.5
• increase in the number of Brn2+ layer II-III neurons in the cortical plate at E14.5 and E16.5
• decrease in the number of basal progenitors (Tbr2+) at E11.5 and E12.5
• decrease in the number of early born layer V and VI neurons at E12.5
• decrease in the number of Ctip2+ layer V and VI neurons, Tbr1+ layer VI neurons and Tbr2+ basal progenitors in the cortex at E14.5 and E16.5
• increase in the number of Cux1+ and Satb2+ upper layer neurons at E18.5
• increase in the number of Brn2+ layer II-III neurons in the cortical plate at E14.5 and E16.5

cellular
• increase in apoptosis at E13.5, primarily located in layers V-VI of the cortex
• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex
• in culture ventricular zone cells are less likely to develop into neurospheres of greater than 50 um in diameter indicating impaired proliferation





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory