All Phenotypes Gabrg2<tm2Geh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gabrg2^tm2Geh
targeted mutation 2, Gregg E Homanics
MGI:3579440

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabrg2^tm2Geh/Gabrg2^tm2Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3582969

Allelic Composition	Gabrg2^tm2Geh/Gabrg2^tm2Geh
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2^tm2Geh mutation (0 available); any Gabrg2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:98560 )

• in the elevated plus maze, had a 74% reduction in open arm entries and an 83% reduction in time on open arms and in the forced novelty expoloration test, had a 28% reduction in locomotor activity, indicating increased anxiety-like behavior, however showed normal hypnotic responses to benzodiazepine site ligands and other sedative/hypnotic drugs tested

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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