Phenotypes associated with this allele

• Allele Symbol: Slc9a4^tm1Ges
• Allele Name: targeted mutation 1, Gary E Shull
• Allele ID: MGI:3579458
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc9a4^tm1Ges/Slc9a4^tm1Ges	involves: 129S6/SvEvTac * Black Swiss	MGI:3581206

Genotype
MGI:3581206

hm1

• Allelic Composition: Slc9a4^tm1Ges/Slc9a4^tm1Ges
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal gastric epithelium in 9 week old Slc9a4^tm1Ges/Slc9a4^tm1Ges mice

digestive/alimentary system

abnormal stomach mucosa morphology ( J:98566 )

• a modest increase in the number of apoptotic and necrotic cells is seen; however no ciliated cells were seen in the gastric mucosa

abnormal gastric chief cell morphology ( J:98566 )

• the number of chief cells appear to be reduced

abnormal gastric parietal cell morphology ( J:98566 )

• the number of parietal cells appear to be reduced

• parietal cells are smaller mostly from a decrease in the cytoplasmic compartment and have abnormal secretory canaliculi

abnormal mucous neck cell morphology ( J:98566 )

• the number of mucous cells is increased

abnormal stomach glandular epithelium morphology ( J:98566 )

• glands in the gastric mucosa appear atrophic with increased interglandular space

• the number of parietal and chief cells appears to be reduced and the number of mucous cells increased, in addition more enteroendocrine and relatively undifferentiated cells are seen

• parietal cells are smaller mostly from a decrease in the cytoplasmic compartment and have abnormal secretory canaliculi

• mucous pit cells often contain intracytoplasmic cystic structures

gastric necrosis ( J:98566 )

hypochlorhydria ( J:98566 )

• the pH of gastric secretions is significantly more alkaline at 18 days, 9 weeks, and 6 months of age but alkalinity does not increase with age

stomach inflammation ( J:98566 )

• some evidence of inflammation including eosinophilic infiltration is seen

endocrine/exocrine glands

abnormal gastric chief cell morphology ( J:98566 )

• the number of chief cells appear to be reduced

abnormal gastric parietal cell morphology ( J:98566 )

• the number of parietal cells appear to be reduced

• parietal cells are smaller mostly from a decrease in the cytoplasmic compartment and have abnormal secretory canaliculi

abnormal mucous neck cell morphology ( J:98566 )

• the number of mucous cells is increased

immune system

stomach inflammation ( J:98566 )

• some evidence of inflammation including eosinophilic infiltration is seen

growth/size/body

growth/size/body region phenotype ( J:98566 )

N • growth and survival are normal