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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agrntm1Rwb
targeted mutation 1, Robert W Burgess
MGI:3579476
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Agrntm1Rwb/Agrntm1Rwb
Tg(APPswe,PSEN1dE9)85Dbo/?
Tg(Tek-cre)1Ywa/? 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL MGI:5692156
cn2
 		Agrntm1Rwb/Agrntm1Rwb
Tg(NPHS2-cre)295Lbh/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3716770
cn3
 		Agrntm1Rwb/Agrntm1Rwb
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3716768
cn4
 		Agrntm1Rwb/Agrntm1Rwb
Tg(Tek-cre)1Ywa/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5692155


Genotype
MGI:5692156
cn1
Allelic
Composition		 Agrntm1Rwb/Agrntm1Rwb
Tg(APPswe,PSEN1dE9)85Dbo/?
Tg(Tek-cre)1Ywa/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrntm1Rwb mutation (1 available); any Agrn mutation (102 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (6 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:220073 )
• elevated Amyloid beta in females mice

homeostasis/metabolism
amyloid beta deposits ( J:220073 )
• elevated Amyloid beta in females mice




Genotype
MGI:3716770
cn2
Allelic
Composition		 Agrntm1Rwb/Agrntm1Rwb
Tg(NPHS2-cre)295Lbh/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrntm1Rwb mutation (1 available); any Agrn mutation (102 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:122821 )
N
• when compared to normal controls, no pathological changes are detected until at least 8 months of age
• glomerular filtration barrier is not compromised in mutants, with normal urinary protein and creatinine levels up to 10 months of age when compared to controls
abnormal renal glomerulus basement membrane morphology ( J:122821 )
• at ~4 months of age, glomerular basement membrane (GBM) abnormalities including focal thickening and epithelial protrusions of GBM material are observed in mutants
increased renal glomerulus basement membrane thickness ( J:122821 )
• focal thickening of the GBM is noted at ~4 months of age




Genotype
MGI:3716768
cn3
Allelic
Composition		 Agrntm1Rwb/Agrntm1Rwb
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrntm1Rwb mutation (1 available); any Agrn mutation (102 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neuromuscular synapse morphology ( J:122821 )
• diaphragms lack neuromuscular junctions

muscle
abnormal diaphragm morphology ( J:122821 )
• diaphragms lack neuromuscular junctions




Genotype
MGI:5692155
cn4
Allelic
Composition		 Agrntm1Rwb/Agrntm1Rwb
Tg(Tek-cre)1Ywa/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrntm1Rwb mutation (1 available); any Agrn mutation (102 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:220073 )
N
• expression of the Agrn gene is restricted to endothelial cells
• no obvious failure of integrity in the blood-brain barrier

cardiovascular system
abnormal blood vessel morphology ( J:220073 )
• decreased diameter of microvessels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory