mortality/aging
• embryos die between E14.5 and E16.5
|
cardiovascular system
• smaller in size
• pulmonary and aortic valve cushions are normal in size at E12.5
|
• all heart valves are similarly affected at E14.5
• heart valve leaflets are shorter and blunt relative to controls
• endocardial cell proliferation in all valves is much reduced while mesenchymal cell proliferation is unchanged
• little apoptosis
|
• mitral and tricuspid valves are much shorter than controls
|
• semilunar valves are 66 or 69% of the control length
|
hemorrhage
(
J:198628
)
• peripheral hemorrhage in most embryos at E15.5
|
• significant at E14.5
|