Phenotypes associated with this allele

• Allele Symbol: Fdft1^tm1Kan
• Allele Name: targeted mutation 1, Klaus-Armin Nave
• Allele ID: MGI:3579504
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fdft1^tm1Kan/Fdft1^tm1Kan Cnp^tm1(cre)Kan/Cnp^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3580007

Genotype
MGI:3580007

cn1

• Allelic Composition: Fdft1^tm1Kan/Fdft1^tm1Kan; Cnp^tm1(cre)Kan/Cnp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:98525 )

• about one-third of mutant mice died between 20 and 30 days

• mutants that survived past 1 month of age rarely died prematurely

nervous system

nervous system phenotype ( J:98525 )

N • homozygous mutant mice that are heterozygous for Cnp1^tm1(cre)Kan, in which cre mediated recombination is induced in oligodendrocyte and Schwann cells, were normal at birth

N • did not reveal any obvious oligodendrocytes loss, or apoptosis

demyelination ( J:98525 )

• severe dysmyelination of the spinal white matter which was almost of devoid of myelin at P20

• the corpus callosum and the cerebellar white matter also showed a marked reduction of myelin

• but no obvious ultrastructural defects in the myelin architecture was found

behavior/neurological

tremors ( J:98525 )

• starting at 2 weeks of age

• the trembling phenotype improved with age

ataxia ( J:98525 )

• starting at 2 weeks of age

impaired coordination ( J:98525 )

• the motor performance on rotarod testing was markedly lower

impaired limb coordination ( J:98525 )

• impaired control of hindlimb movements starting at 2 weeks of age

growth/size/body

postnatal growth retardation ( J:98525 )

• mutant mice lagged behind controls in weight gain

reproductive system

reduced fertility ( J:98525 )

• overall breeding performance was poor