Phenotypes associated with this allele

• Allele Symbol: Itgad^tm1Bll
• Allele Name: targeted mutation 1, Christie M Ballantyne
• Allele ID: MGI:3579559
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgad^tm1Bll/Itgad^tm1Bll	B6.129S7-Itgad^tm1Bll	MGI:3583102

Genotype
MGI:3583102

hm1

• Allelic Composition: Itgad^tm1Bll/Itgad^tm1Bll
• Genetic Background: B6.129S7-Itgad^tm1Bll

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte cell number ( J:90954 )

• SEA injection induced less of a decrease in the numbers of thymocytes than in wild-type

abnormal T cell subpopulation ratio ( J:90954 )

• significantly lower ratio of CD4+ to CD8+ cells in splenocytes and thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:90954 )

• decreased numbers of CD4+ cells in splenocytes and thymocytes

increased CD8-positive, alpha-beta T cell number ( J:90954 )

• increased numbers of CD8+ cells in splenocytes and thymocytes

abnormal T cell activation ( J:90954 )

• splenocytes responded poorly to PHA and ConA stimulation, indicating poor T cell activation

decreased T cell proliferation ( J:90954 )

• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice

hematopoietic system

abnormal lymphocyte cell number ( J:90954 )

• SEA injection induced less of a decrease in the numbers of thymocytes than in wild-type

abnormal T cell subpopulation ratio ( J:90954 )

• significantly lower ratio of CD4+ to CD8+ cells in splenocytes and thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:90954 )

• decreased numbers of CD4+ cells in splenocytes and thymocytes

increased CD8-positive, alpha-beta T cell number ( J:90954 )

• increased numbers of CD8+ cells in splenocytes and thymocytes

abnormal T cell activation ( J:90954 )

• splenocytes responded poorly to PHA and ConA stimulation, indicating poor T cell activation

decreased T cell proliferation ( J:90954 )

• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice

cellular

decreased T cell proliferation ( J:90954 )

• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice