Analysis Tools
immune system
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• mutant T cells from mice immunized with EAE proliferate more than controls to the high amounts of MOG peptide
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• T cells from immunized mice secrete less IFN-gamma than controls
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• T cells from immunized mice secrete 1.5-fold more IL-12 than controls
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• T cells from immunized mice secrete less IL-17 than controls
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• T cells from immunized mice secrete more IL-2 than controls
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• T cells from immunized mice secrete less TNF than controls
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• the chronic phase of MOG induced EAE is attenuated with a significantly lower cumulative disease score compared to controls
• there is little cellular infiltration, inflammation, axonal degeneration, and demyelination in the spinal cord of these mice compared to controls
• CD4+ and CD8+ T-cell infiltration is reduced 94.5 and 95.8%, respectively, compared with wild-type mice
• transfer of wild-type MOG-activated T cells into mutant mice leads to slightly attenuated form of EAE
• transfer of mutant T cells into wild-type mice leads to a mild, acute disease
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• mice are more susceptible to pneumococcal infection than controls
• when challenged with a PspA+ bacterial strain, 75% of mice die within 72 hours compared to 58% of wild-type mice
• when challenged with a PspA- bacterial strain, mice have a 100-fold higher burden 4 hours after infection
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hematopoietic system
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• mutant T cells from mice immunized with EAE proliferate more than controls to the high amounts of MOG peptide
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cellular
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• mutant T cells from mice immunized with EAE proliferate more than controls to the high amounts of MOG peptide
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