Phenotypes associated with this allele

• Allele Symbol: Gnas^tm2Kel
• Allele Name: targeted mutation 2, Gavin Kelsey
• Allele ID: MGI:3579575
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gnas^tm2Kel/Gnas^+	either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:3583684

Genotype
MGI:3583684

ht1

• Allelic Composition: Gnas^tm2Kel/Gnas⁺
• Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to new environment ( J:97634 )

• heterozygotes with a maternally inherited allele made more entries into a novel environment but spent less time in the novel environment

hyperactivity ( J:97634 )

• increased activity is seen in heterozygotes with a maternally inherited allele on the first day of testing; however both groups habituated over time

nervous system

nervous system phenotype ( J:97634 )

N • whole tissue levels of norepinephrine, dopamine and 5-hydroxytryptamine are normal

cellular

paternal imprinting ( J:97634 )

• heterozygotes inheriting the allele from the mother display a phenotype while heterozygotes inheriting the allele from the father are similar to wild-type and are used as controls