Phenotypes associated with this allele

• Allele Symbol: H1f7^tm1Idvd
• Allele Name: targeted mutation 1, Irwin Davidson
• Allele ID: MGI:3579810
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H1f7^tm1Idvd/H1f7^tm1Idvd	Not Specified	MGI:3580400

Genotype
MGI:3580400

hm1

• Allelic Composition: H1f7^tm1Idvd/H1f7^tm1Idvd
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:96828 )

♂ • reduced sperm count and more than 80% of sperm in the cauda epididymides have TUNEL positive nuclei

abnormal sperm head morphology ( J:96828 )

♂ • the spermatid head is irregularly shaped with a bent or blunted apex and malformations are seen in more than 80% of spermatozoa

detached acrosome ( J:96828 )

♂

abnormal sperm nucleus morphology ( J:96828 )

♂ • defective DNA condensation within the sperm nucleus during spermiogenesis

asthenozoospermia ( J:96828 )

♂ • the majority of sperm cells are slow moving or static

abnormal spermiogenesis ( J:96828 )

♂ • mutant spermatids fail to polarize properly, leading to incomplete elongation and retention of cytoplasm or residual bodies as well as delayed DNA condensation

reduced male fertility ( J:96828 )

♂ • male but not female fertility is reduced

cellular

oligozoospermia ( J:96828 )

♂ • reduced sperm count and more than 80% of sperm in the cauda epididymides have TUNEL positive nuclei

abnormal sperm head morphology ( J:96828 )

♂ • the spermatid head is irregularly shaped with a bent or blunted apex and malformations are seen in more than 80% of spermatozoa

detached acrosome ( J:96828 )

♂

abnormal sperm nucleus morphology ( J:96828 )

♂ • defective DNA condensation within the sperm nucleus during spermiogenesis

asthenozoospermia ( J:96828 )

♂ • the majority of sperm cells are slow moving or static