Phenotypes associated with this allele

• Allele Symbol: Kcp^tm1Gdr
• Allele Name: targeted mutation 1, Gregory R Dressler
• Allele ID: MGI:3579811
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcp^tm1Gdr/Kcp^tm1Gdr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3580502

Genotype
MGI:3580502

hm1

• Allelic Composition: Kcp^tm1Gdr/Kcp^tm1Gdr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:97529 )

• 2 days after folic acid injection (250 mg/kg) to induce acute tubular necrosis more than 23% of homozygotes had died compared to less than 2% of wild-type mice

renal/urinary system

renal interstitial fibrosis ( J:97529 )

• in the unilater ureteral obstruction model of fibrosis a 2-fold increase in fibrosis is seen in the obstructed kidney and fibrosis is also seen in the contralateral kidney unlike in wild-type mice

• in the absence of treatment homozygotes do not display any gross malformations and are fertile

homeostasis/metabolism

abnormal response to vitamins ( J:97529 )

• by 7 days after folic acid injection (250 mg/kg) to induce acute tubular necrosis cortical cysts and extracellular matrix deposition are seen in mutant kidneys while wild-type kidneys show nearly complete recovery

• by 28 days after folic acid injection (250 mg/kg) substantial kidney scarring is still seen