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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pram1tm1Gak
targeted mutation 1, Gary A Koretzky
MGI:3579812
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pram1tm1Gak/Pram1tm1Gak involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3580793


Genotype
MGI:3580793
hm1
Allelic
Composition		 Pram1tm1Gak/Pram1tm1Gak
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pram1tm1Gak mutation (0 available); any Pram1 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:95253 )
• neutrophils had defects in integrin-mediated responses as exhibited by decreased adhesion-dependent reactive oxygen intermediate (ROI) production and degranulation, however exhibited normal numbers of neutrophils and normal ability to kill bacteria

hematopoietic system
abnormal neutrophil physiology ( J:95253 )
• neutrophils had defects in integrin-mediated responses as exhibited by decreased adhesion-dependent reactive oxygen intermediate (ROI) production and degranulation, however exhibited normal numbers of neutrophils and normal ability to kill bacteria




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory