About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pram1tm1Gak
targeted mutation 1, Gary A Koretzky
MGI:3579812
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pram1tm1Gak/Pram1tm1Gak involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3580793


Genotype
MGI:3580793
hm1
Allelic
Composition		 Pram1tm1Gak/Pram1tm1Gak
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pram1tm1Gak mutation (0 available); any Pram1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:95253 )
• neutrophils had defects in integrin-mediated responses as exhibited by decreased adhesion-dependent reactive oxygen intermediate (ROI) production and degranulation, however exhibited normal numbers of neutrophils and normal ability to kill bacteria

hematopoietic system
abnormal neutrophil physiology ( J:95253 )
• neutrophils had defects in integrin-mediated responses as exhibited by decreased adhesion-dependent reactive oxygen intermediate (ROI) production and degranulation, however exhibited normal numbers of neutrophils and normal ability to kill bacteria




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory