All Phenotypes Sycp1<tm1Aps> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sycp1^tm1Aps/Sycp1^tm1Aps	involves: 129P2/OlaHsd * C57BL/6	MGI:3581192
hm2	Sycp1^tm1Aps/Sycp1^tm1Aps	involves: 129P2/OlaHsd * C57BL/6J	MGI:5438290

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal female reproductive system morphology ( J:98718 )

absent ovarian follicles ( J:98718 )

• growing ovarian follicles and oocytes are absent

decreased ovary weight ( J:98718 )

• ovaries weight about 35% less than wild-type

abnormal gametogenesis ( J:98718 )

azoospermia ( J:98718 )

abnormal male meiosis ( J:98718 )

• axial elements are formed and chromosomes align; however, synapses are not formed

arrest of male meiosis ( J:98718 )

• most spermatocytes arrest at the pachytene stage with increased apoptosis seen at pachynema and from 0-3% of spermatocytes reaching diplonema

abnormal male reproductive system morphology ( J:98718 )

small seminiferous tubules ( J:98718 )

decreased testis weight ( J:98718 )

• testes weigh about 70% less than wild-type

female infertility ( J:98718 )

male infertility ( J:98718 )

endocrine/exocrine glands

absent ovarian follicles ( J:98718 )

• growing ovarian follicles and oocytes are absent

decreased ovary weight ( J:98718 )

• ovaries weight about 35% less than wild-type

small seminiferous tubules ( J:98718 )

decreased testis weight ( J:98718 )

• testes weigh about 70% less than wild-type

cellular

azoospermia ( J:98718 )

abnormal male meiosis ( J:98718 )

• axial elements are formed and chromosomes align; however, synapses are not formed

arrest of male meiosis ( J:98718 )

• most spermatocytes arrest at the pachytene stage with increased apoptosis seen at pachynema and from 0-3% of spermatocytes reaching diplonema

Allelic Composition	Sycp1^tm1Aps/Sycp1^tm1Aps
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sycp1^tm1Aps mutation (0 available); any Sycp1 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:187173 )

• synaptonemal complexes fail to form central elements

• more numerous and abnormal chiasma-like structures form with conjoined or fused axes

• diplotene cells exhibit non-centromeric ends of the homolog axes fused to form contiguous terminal loops

• centromere pairing is reduced compared to in wild-type cells sister-chromatid individualization is exaggerated compared to in wild-type cells

• centromeric termini are more fragile and fractured in appearance compared to in wild-type cells