Phenotypes associated with this allele

• Allele Symbol: Dst^dt-37J
• Allele Name: dystonia musculorum 37, Jackson
• Allele ID: MGI:3580065
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dst^dt-37J/Dst^dt-37J	C57BL/6J-Dst^dt-37J/J	MGI:3580067

Genotype
MGI:3580067

hm1

• Allelic Composition: Dst^dt-37J/Dst^dt-37J
• Genetic Background: C57BL/6J-Dst^dt-37J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:82238 )

• mutant mice take a few seconds to right themselves from a back-lying position

dystonia ( J:82238 )

• mutant mice exhibit flaccid paralysis of the fore- and hindlimbs, with an average age of onset of 2.8 weeks

• no muscle tonus is evident when a limb is gently pulled

• locomotion is achieved by the mouse's rocking on its belly

• front limbs remain flexed at the elbow and hind legs drag behind

• when a mutant mouse is picked up by the tail, the front and rear legs come together, the forelimbs dropping backward and the hindlimbs pulled forward

growth/size/body

decreased body size ( J:82238 )

nervous system

chromatolysis ( J:82238 )

• neurons of the brainstem and spinal cord of 18-21 day old mutant mice exhibit central chromatolysis

axonal dystrophy ( J:82238 )

• axons of brainstem and spinal cord neurons of 18-21 day old mutants are dystrophic

demyelination ( J:82238 )

• degeneration of the myelin of peripheral nerves of 18-21 day old mutants is evidenced by myelin figures present in their cytoplasm

hematopoietic system

decreased bone marrow cell number ( J:82238 )

• bone marrow of 21-day-old mutants is hypoplastic

muscle

dystonia ( J:82238 )

• mutant mice exhibit flaccid paralysis of the fore- and hindlimbs, with an average age of onset of 2.8 weeks

• no muscle tonus is evident when a limb is gently pulled

• locomotion is achieved by the mouse's rocking on its belly

• front limbs remain flexed at the elbow and hind legs drag behind

• when a mutant mouse is picked up by the tail, the front and rear legs come together, the forelimbs dropping backward and the hindlimbs pulled forward

decreased skeletal muscle fiber size ( J:82238 )

• the size of muscle fibers is reduced in 21-day old mutant mice