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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arhgap6/Hccs/Mid1tm1Hzo
targeted mutation 1, Huda Y Zoghbi
MGI:3580071
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo involves: 129S7/SvEvBrd MGI:3580081
cn2
Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo
Tg(EIIa-cre)C5379Lmgd/?
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3580089
cn3
Arhgap6/Hccs/Mid1tm1Hzo/Y
Tg(EIIa-cre)C5379Lmgd/?
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3580090
cn4
Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6+
Tg(EIIa-cre)C5379Lmgd/?
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3580093
ot5
Arhgap6/Hccs/Mid1tm1Hzo/Y involves: 129S7/SvEvBrd MGI:3580082


Genotype
MGI:3580081
hm1
Allelic
Composition
Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Arhgap6 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3580089
cn2
Allelic
Composition
Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6/Hccs/Mid1tm1Hzo
Tg(EIIa-cre)C5379Lmgd/?
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Arhgap6 mutation (9 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 15 of 21 embryos abnormal at E9.5 and E10.5
• mosaic animals were present and were healthy and fertile
• no homozygous mice born

embryo
• many embryos undergoing resorption by E9.5-E10.5
• gastrulation defects

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microphthalmia DOID:10629 J:80528




Genotype
MGI:3580090
cn3
Allelic
Composition
Arhgap6/Hccs/Mid1tm1Hzo/Y
Tg(EIIa-cre)C5379Lmgd/?
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Arhgap6 mutation (9 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no hemizygous mice born
• 15 of 21 embryos abnormal at E9.5 and E10.5
• mosaic animals were present and were healthy and fertile

embryo
• many embryos undergoing resorption by E9.5-E10.5
• gastrulation defects

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microphthalmia DOID:10629 J:80528




Genotype
MGI:3580093
cn4
Allelic
Composition
Arhgap6/Hccs/Mid1tm1Hzo/Arhgap6+
Tg(EIIa-cre)C5379Lmgd/?
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Arhgap6 mutation (9 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no heterozygotes born

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microphthalmia DOID:10629 J:80528




Genotype
MGI:3580082
ot5
Allelic
Composition
Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap6/Hccs/Mid1tm1Hzo mutation (0 available); any Arhgap6 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





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last database update
09/03/2024
MGI 6.24
The Jackson Laboratory