Phenotypes associated with this allele

• Allele Symbol: Hnrnpu^{Gt(U3Neo)1Rul}
• Allele Name: gene trap 1, H Earl Ruley
• Allele ID: MGI:3580289
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hnrnpu^Gt(U3Neo)1Rul/Hnrnpu^Gt(U3Neo)1Rul	either: B6.129S2-Hnrnpu^Gt(U3Neo)1Rul or (involves: 129S2/SvPas * C57BL/6J)	MGI:3580461

Genotype
MGI:3580461

hm1

• Allelic Composition: Hnrnpu^{Gt(U3Neo)1Rul}/Hnrnpu^{Gt(U3Neo)1Rul}
• Genetic Background: either: B6.129S2-Hnrnpu^{Gt(U3Neo)1Rul} or (involves: 129S2/SvPas * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98861 )

• about 2/3 of homozygous embryos are resorbed by E9.5 - E10.5 with no homozygotes found after E11.5

embryo

abnormal ectoderm development ( J:98861 )

• at E7.5 the embryonic ectoderm is small and underdeveloped

embryonic growth retardation ( J:98861 )

• at E7.5 homozygotes have not yet undergone gastrulation and lack a neural groove appearing similar to E6.5 embryos

• at E9.5 homozygous embryos resemble E8.5 embryos

abnormal extraembryonic tissue morphology ( J:98861 )

• at E7.5 extraembryonic tissues are not as severey effected as embryonic tissues but appear smaller and are disorganized without any identifiable cavities or membranes

• at E8.5 some disorganized extraembryonic cavities and membranes are seen

failure of chorioallantoic fusion ( J:98861 )

• the allantois and chorion do not fuse; however the allantois continues to grow resulting in a large spherical morphology

growth/size/body

embryonic growth retardation ( J:98861 )

• at E7.5 homozygotes have not yet undergone gastrulation and lack a neural groove appearing similar to E6.5 embryos

• at E9.5 homozygous embryos resemble E8.5 embryos